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Case report: Severe deep ulcer on the left abdomen mimicking mycosis fungoides caused by Trichophyton tonsurans in a patient with novel CARD9 mutation

Dermatophytosis is the most common type of superficial fungal infection caused by dermatophytes. Occasionally, the fungus invades deep into the dermis or other tissues, causing deep dermatophytosis. Deep dermatophytosis is often associated with Caspase Recruitment Domain-containing protein 9 (CARD9)...

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Autores principales: Tan, Jingwen, Yu, Qian, Gao, Zhiqin, Yang, Hong, Chen, Qilong, Yang, Lianjuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554596/
https://www.ncbi.nlm.nih.gov/pubmed/36248888
http://dx.doi.org/10.3389/fimmu.2022.1015000
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author Tan, Jingwen
Yu, Qian
Gao, Zhiqin
Yang, Hong
Chen, Qilong
Yang, Lianjuan
author_facet Tan, Jingwen
Yu, Qian
Gao, Zhiqin
Yang, Hong
Chen, Qilong
Yang, Lianjuan
author_sort Tan, Jingwen
collection PubMed
description Dermatophytosis is the most common type of superficial fungal infection caused by dermatophytes. Occasionally, the fungus invades deep into the dermis or other tissues, causing deep dermatophytosis. Deep dermatophytosis is often associated with Caspase Recruitment Domain-containing protein 9 (CARD9) deficiency in patients. Here, we report the first case of deep dermatophytosis with a rare mycosis fungoides manifestation caused by T. tonsurans in a patient with a novel mutation in exon 4 of CARD9. The condition presented with heterozygous K196E mutation, which leads to deficiency of innate and adaptive immune responses in the patient, and caused intractable severe lesions. The patient received treatment with multiple antifungal drugs and was ultimately alleviated by posaconazole. These findings extend the pathogen spectrum of deep dermatophytosis linked with CARD9 deficiency and enriched their phenotypic spectrum.
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spelling pubmed-95545962022-10-13 Case report: Severe deep ulcer on the left abdomen mimicking mycosis fungoides caused by Trichophyton tonsurans in a patient with novel CARD9 mutation Tan, Jingwen Yu, Qian Gao, Zhiqin Yang, Hong Chen, Qilong Yang, Lianjuan Front Immunol Immunology Dermatophytosis is the most common type of superficial fungal infection caused by dermatophytes. Occasionally, the fungus invades deep into the dermis or other tissues, causing deep dermatophytosis. Deep dermatophytosis is often associated with Caspase Recruitment Domain-containing protein 9 (CARD9) deficiency in patients. Here, we report the first case of deep dermatophytosis with a rare mycosis fungoides manifestation caused by T. tonsurans in a patient with a novel mutation in exon 4 of CARD9. The condition presented with heterozygous K196E mutation, which leads to deficiency of innate and adaptive immune responses in the patient, and caused intractable severe lesions. The patient received treatment with multiple antifungal drugs and was ultimately alleviated by posaconazole. These findings extend the pathogen spectrum of deep dermatophytosis linked with CARD9 deficiency and enriched their phenotypic spectrum. Frontiers Media S.A. 2022-09-28 /pmc/articles/PMC9554596/ /pubmed/36248888 http://dx.doi.org/10.3389/fimmu.2022.1015000 Text en Copyright © 2022 Tan, Yu, Gao, Yang, Chen and Yang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Tan, Jingwen
Yu, Qian
Gao, Zhiqin
Yang, Hong
Chen, Qilong
Yang, Lianjuan
Case report: Severe deep ulcer on the left abdomen mimicking mycosis fungoides caused by Trichophyton tonsurans in a patient with novel CARD9 mutation
title Case report: Severe deep ulcer on the left abdomen mimicking mycosis fungoides caused by Trichophyton tonsurans in a patient with novel CARD9 mutation
title_full Case report: Severe deep ulcer on the left abdomen mimicking mycosis fungoides caused by Trichophyton tonsurans in a patient with novel CARD9 mutation
title_fullStr Case report: Severe deep ulcer on the left abdomen mimicking mycosis fungoides caused by Trichophyton tonsurans in a patient with novel CARD9 mutation
title_full_unstemmed Case report: Severe deep ulcer on the left abdomen mimicking mycosis fungoides caused by Trichophyton tonsurans in a patient with novel CARD9 mutation
title_short Case report: Severe deep ulcer on the left abdomen mimicking mycosis fungoides caused by Trichophyton tonsurans in a patient with novel CARD9 mutation
title_sort case report: severe deep ulcer on the left abdomen mimicking mycosis fungoides caused by trichophyton tonsurans in a patient with novel card9 mutation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554596/
https://www.ncbi.nlm.nih.gov/pubmed/36248888
http://dx.doi.org/10.3389/fimmu.2022.1015000
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