Cargando…
Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone
BACKGROUND: Population and study's methodology heterogenicity became clinical evolution of chronic spontaneous urticaria (CSU) highly variable. OBJECTIVE: In a prospective cohort, we evaluated the different pathways of clinical evolution of CSU and identified possible risk factors. METHODS: A t...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
World Allergy Organization
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554810/ https://www.ncbi.nlm.nih.gov/pubmed/36267098 http://dx.doi.org/10.1016/j.waojou.2022.100705 |
_version_ | 1784806781408509952 |
---|---|
author | Sánchez, Jorge Álvarez, Leidy Cardona, Ricardo |
author_facet | Sánchez, Jorge Álvarez, Leidy Cardona, Ricardo |
author_sort | Sánchez, Jorge |
collection | PubMed |
description | BACKGROUND: Population and study's methodology heterogenicity became clinical evolution of chronic spontaneous urticaria (CSU) highly variable. OBJECTIVE: In a prospective cohort, we evaluated the different pathways of clinical evolution of CSU and identified possible risk factors. METHODS: A total of 685 CSU patients (>12 years) were prospectively followed over 5 years. Diagnosis and follow-up of urticaria were based on medical evaluation and photographic records. Remission was defined as at least 6 months without symptoms (hives, angioedema, or pruritus) and medication. The follow-up included at least 2 visits per year, with photographic registration and clinical evaluation. Predefined clinical and paraclinical variables were included in the regression analyses. RESULTS: We identified four clinical evolution pathways; The cumulative prevalence of remission at 5 years was 59.1%, recurrence was 17.1%, persistence was 11.6%, and chronic pruritus without hives or angioedema was 12.2%. The probability of persistence increased with hypothyroidism diagnosis (HR 0.425, 95% CI 0.290–0.621) and each point in the UAS7 (HR 0.931 95% CI 0.918–0.945). CONCLUSION: Chronic urticaria has different evolutions. Disease activity and hypothyroidism predict persistence and remission. Recurrence and chronic pruritus phenotypes require further study to evaluate their causality and prognosis. |
format | Online Article Text |
id | pubmed-9554810 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | World Allergy Organization |
record_format | MEDLINE/PubMed |
spelling | pubmed-95548102022-10-19 Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone Sánchez, Jorge Álvarez, Leidy Cardona, Ricardo World Allergy Organ J Full-Length Article BACKGROUND: Population and study's methodology heterogenicity became clinical evolution of chronic spontaneous urticaria (CSU) highly variable. OBJECTIVE: In a prospective cohort, we evaluated the different pathways of clinical evolution of CSU and identified possible risk factors. METHODS: A total of 685 CSU patients (>12 years) were prospectively followed over 5 years. Diagnosis and follow-up of urticaria were based on medical evaluation and photographic records. Remission was defined as at least 6 months without symptoms (hives, angioedema, or pruritus) and medication. The follow-up included at least 2 visits per year, with photographic registration and clinical evaluation. Predefined clinical and paraclinical variables were included in the regression analyses. RESULTS: We identified four clinical evolution pathways; The cumulative prevalence of remission at 5 years was 59.1%, recurrence was 17.1%, persistence was 11.6%, and chronic pruritus without hives or angioedema was 12.2%. The probability of persistence increased with hypothyroidism diagnosis (HR 0.425, 95% CI 0.290–0.621) and each point in the UAS7 (HR 0.931 95% CI 0.918–0.945). CONCLUSION: Chronic urticaria has different evolutions. Disease activity and hypothyroidism predict persistence and remission. Recurrence and chronic pruritus phenotypes require further study to evaluate their causality and prognosis. World Allergy Organization 2022-10-08 /pmc/articles/PMC9554810/ /pubmed/36267098 http://dx.doi.org/10.1016/j.waojou.2022.100705 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Full-Length Article Sánchez, Jorge Álvarez, Leidy Cardona, Ricardo Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone |
title | Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone |
title_full | Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone |
title_fullStr | Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone |
title_full_unstemmed | Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone |
title_short | Prospective analysis of clinical evolution in chronic urticaria: Persistence, remission, recurrence, and pruritus alone |
title_sort | prospective analysis of clinical evolution in chronic urticaria: persistence, remission, recurrence, and pruritus alone |
topic | Full-Length Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554810/ https://www.ncbi.nlm.nih.gov/pubmed/36267098 http://dx.doi.org/10.1016/j.waojou.2022.100705 |
work_keys_str_mv | AT sanchezjorge prospectiveanalysisofclinicalevolutioninchronicurticariapersistenceremissionrecurrenceandpruritusalone AT alvarezleidy prospectiveanalysisofclinicalevolutioninchronicurticariapersistenceremissionrecurrenceandpruritusalone AT cardonaricardo prospectiveanalysisofclinicalevolutioninchronicurticariapersistenceremissionrecurrenceandpruritusalone |