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Reactivity and binding mode of disulfiram, its metabolites, and derivatives in SARS-CoV-2 PL(pro): insights from computational chemistry studies
The papain-like protease (PL(pro)) from SARS-CoV-2 is an important target for the development of antivirals against COVID-19. The safe drug disulfiram (DSF) presents antiviral activity inhibiting PL(pro) in vitro, and it is under clinical trial studies, indicating to be a promising anti-COVID-19 dru...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554863/ https://www.ncbi.nlm.nih.gov/pubmed/36222962 http://dx.doi.org/10.1007/s00894-022-05341-2 |