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Mesoporous Silica Nanoparticles Improve Oral Delivery of Antitubercular Bicyclic Nitroimidazoles

[Image: see text] Pretomanid and MCC7433, a novel nitroimidazopyrazinone analog, are promising antitubercular agents that belong to the bicyclic nitroimidazole family. Despite possessing high cell permeability, they suffer from poor aqueous solubility and require specialized formulations in order to...

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Detalles Bibliográficos
Autores principales:	Ang, Chee Wei, Tan, Lendl, Qu, Zhi, West, Nicholas P., Cooper, Matthew A., Popat, Amirali, Blaskovich, Mark A.T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554870/ https://www.ncbi.nlm.nih.gov/pubmed/34464089 http://dx.doi.org/10.1021/acsbiomaterials.1c00807

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