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Hyperhomocysteinemia and intracranial aneurysm: A mendelian randomization study
OBJECTIVE: To investigate the link between genetic variants associated with plasma homocysteine levels and risk of intracranial aneurysm (IA) using two-sample Mendelian randomization. METHODS: We used single-nucleotide polymorphisms associated with human plasma homocysteine levels as instrumental va...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554923/ https://www.ncbi.nlm.nih.gov/pubmed/36247759 http://dx.doi.org/10.3389/fneur.2022.948989 |
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author | Ma, Chencheng Zhang, Weiwei Mao, Lei Zhang, Guangjian Shen, Yuqi Chang, Hanxiao Xu, Xiupeng Li, Zheng Lu, Hua |
author_facet | Ma, Chencheng Zhang, Weiwei Mao, Lei Zhang, Guangjian Shen, Yuqi Chang, Hanxiao Xu, Xiupeng Li, Zheng Lu, Hua |
author_sort | Ma, Chencheng |
collection | PubMed |
description | OBJECTIVE: To investigate the link between genetic variants associated with plasma homocysteine levels and risk of intracranial aneurysm (IA) using two-sample Mendelian randomization. METHODS: We used single-nucleotide polymorphisms associated with human plasma homocysteine levels as instrumental variables for the primary analysis in a genome-wide association study of 44,147 subjects of European ancestry. Summary-level statistics were obtained for 79,429 individuals, including 7,495 IA cases and 71,934 controls. To enhance validity, five different Mendelian randomization methods (MR-Egger, weighted median, inverse variance weighted, simple mode, and weighted mode) were used for the analyses. RESULTS: The inverse variance weighted analysis method produced P-values of 0.398 for aneurysmal subarachnoid hemorrhage [odds ratio (OR): 1.104; 95% confidence interval (CI): 0.878–1.387], 0.246 for IA (OR: 1.124; 95% CI: 0.923–1.368), and 0.644 for unruptured IA (OR: 1.126; 95% CI: 0.682–1.858). The MR-Egger analysis showed no association between IAs and homocysteine, with all P > 0.05. CONCLUSION: Using gene-related instrumental variables, the Mendelian randomization analyses demonstrated a lack of an association between plasma homocysteine levels and IAs or aneurysmal subarachnoid hemorrhage. |
format | Online Article Text |
id | pubmed-9554923 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95549232022-10-13 Hyperhomocysteinemia and intracranial aneurysm: A mendelian randomization study Ma, Chencheng Zhang, Weiwei Mao, Lei Zhang, Guangjian Shen, Yuqi Chang, Hanxiao Xu, Xiupeng Li, Zheng Lu, Hua Front Neurol Neurology OBJECTIVE: To investigate the link between genetic variants associated with plasma homocysteine levels and risk of intracranial aneurysm (IA) using two-sample Mendelian randomization. METHODS: We used single-nucleotide polymorphisms associated with human plasma homocysteine levels as instrumental variables for the primary analysis in a genome-wide association study of 44,147 subjects of European ancestry. Summary-level statistics were obtained for 79,429 individuals, including 7,495 IA cases and 71,934 controls. To enhance validity, five different Mendelian randomization methods (MR-Egger, weighted median, inverse variance weighted, simple mode, and weighted mode) were used for the analyses. RESULTS: The inverse variance weighted analysis method produced P-values of 0.398 for aneurysmal subarachnoid hemorrhage [odds ratio (OR): 1.104; 95% confidence interval (CI): 0.878–1.387], 0.246 for IA (OR: 1.124; 95% CI: 0.923–1.368), and 0.644 for unruptured IA (OR: 1.126; 95% CI: 0.682–1.858). The MR-Egger analysis showed no association between IAs and homocysteine, with all P > 0.05. CONCLUSION: Using gene-related instrumental variables, the Mendelian randomization analyses demonstrated a lack of an association between plasma homocysteine levels and IAs or aneurysmal subarachnoid hemorrhage. Frontiers Media S.A. 2022-09-28 /pmc/articles/PMC9554923/ /pubmed/36247759 http://dx.doi.org/10.3389/fneur.2022.948989 Text en Copyright © 2022 Ma, Zhang, Mao, Zhang, Shen, Chang, Xu, Li and Lu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Ma, Chencheng Zhang, Weiwei Mao, Lei Zhang, Guangjian Shen, Yuqi Chang, Hanxiao Xu, Xiupeng Li, Zheng Lu, Hua Hyperhomocysteinemia and intracranial aneurysm: A mendelian randomization study |
title | Hyperhomocysteinemia and intracranial aneurysm: A mendelian randomization study |
title_full | Hyperhomocysteinemia and intracranial aneurysm: A mendelian randomization study |
title_fullStr | Hyperhomocysteinemia and intracranial aneurysm: A mendelian randomization study |
title_full_unstemmed | Hyperhomocysteinemia and intracranial aneurysm: A mendelian randomization study |
title_short | Hyperhomocysteinemia and intracranial aneurysm: A mendelian randomization study |
title_sort | hyperhomocysteinemia and intracranial aneurysm: a mendelian randomization study |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554923/ https://www.ncbi.nlm.nih.gov/pubmed/36247759 http://dx.doi.org/10.3389/fneur.2022.948989 |
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