Tumor necrosis factor inhibitors for pediatric patients with SAPHO syndrome associated with acne conglobata

Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare chronic inflammatory disease with osteoarticular and cutaneous involvements as its main manifestations. Acne conglobata as a severe acne form may affect adolescent patients. Tumor necrosis factor inhibitors are usuall...

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Autores principales: Liu, Shengyan, Wu, Xia, Cao, Yihan, Li, Zhaohui, Liu, Yuchen, Ma, Mingwei, Li, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555096/
https://www.ncbi.nlm.nih.gov/pubmed/36224598
http://dx.doi.org/10.1186/s12969-022-00749-9
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author Liu, Shengyan
Wu, Xia
Cao, Yihan
Li, Zhaohui
Liu, Yuchen
Ma, Mingwei
Li, Chen
author_facet Liu, Shengyan
Wu, Xia
Cao, Yihan
Li, Zhaohui
Liu, Yuchen
Ma, Mingwei
Li, Chen
author_sort Liu, Shengyan
collection PubMed
description Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare chronic inflammatory disease with osteoarticular and cutaneous involvements as its main manifestations. Acne conglobata as a severe acne form may affect adolescent patients. Tumor necrosis factor inhibitors are usually used as a second-line therapy for refractory SAPHO syndrome and has been reported to treat acne conglobata successfully. We herein report three cases of adolescent patients with SAPHO syndrome associated with acne conglobata who were successfully treated with TNFi therapy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12969-022-00749-9.
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spelling pubmed-95550962022-10-13 Tumor necrosis factor inhibitors for pediatric patients with SAPHO syndrome associated with acne conglobata Liu, Shengyan Wu, Xia Cao, Yihan Li, Zhaohui Liu, Yuchen Ma, Mingwei Li, Chen Pediatr Rheumatol Online J Letter to the Editor Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare chronic inflammatory disease with osteoarticular and cutaneous involvements as its main manifestations. Acne conglobata as a severe acne form may affect adolescent patients. Tumor necrosis factor inhibitors are usually used as a second-line therapy for refractory SAPHO syndrome and has been reported to treat acne conglobata successfully. We herein report three cases of adolescent patients with SAPHO syndrome associated with acne conglobata who were successfully treated with TNFi therapy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12969-022-00749-9. BioMed Central 2022-10-12 /pmc/articles/PMC9555096/ /pubmed/36224598 http://dx.doi.org/10.1186/s12969-022-00749-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Letter to the Editor
Liu, Shengyan
Wu, Xia
Cao, Yihan
Li, Zhaohui
Liu, Yuchen
Ma, Mingwei
Li, Chen
Tumor necrosis factor inhibitors for pediatric patients with SAPHO syndrome associated with acne conglobata
title Tumor necrosis factor inhibitors for pediatric patients with SAPHO syndrome associated with acne conglobata
title_full Tumor necrosis factor inhibitors for pediatric patients with SAPHO syndrome associated with acne conglobata
title_fullStr Tumor necrosis factor inhibitors for pediatric patients with SAPHO syndrome associated with acne conglobata
title_full_unstemmed Tumor necrosis factor inhibitors for pediatric patients with SAPHO syndrome associated with acne conglobata
title_short Tumor necrosis factor inhibitors for pediatric patients with SAPHO syndrome associated with acne conglobata
title_sort tumor necrosis factor inhibitors for pediatric patients with sapho syndrome associated with acne conglobata
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555096/
https://www.ncbi.nlm.nih.gov/pubmed/36224598
http://dx.doi.org/10.1186/s12969-022-00749-9
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