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Efficacy of split-thickness skin graft combined with novel sheet-type reprocessed micronized acellular dermal matrix
BACKGROUND: Autologous split-thickness skin grafts (STSGs) remain the mainstay for treatment of large skin defects. Despite its many advantages, there exist critical disadvantages such as unfavorable scar and graft contracture. In addition, it cannot be used when structures such as tendons and bones...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555098/ https://www.ncbi.nlm.nih.gov/pubmed/36221130 http://dx.doi.org/10.1186/s12893-022-01801-x |
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author | Hahn, Hyung Min Jeong, Yon Soo Lee, Il Jae Kim, Min Ji Lim, Hyoseob |
author_facet | Hahn, Hyung Min Jeong, Yon Soo Lee, Il Jae Kim, Min Ji Lim, Hyoseob |
author_sort | Hahn, Hyung Min |
collection | PubMed |
description | BACKGROUND: Autologous split-thickness skin grafts (STSGs) remain the mainstay for treatment of large skin defects. Despite its many advantages, there exist critical disadvantages such as unfavorable scar and graft contracture. In addition, it cannot be used when structures such as tendons and bones are exposed. To overcome these limitations, acellular dermal matrix (ADM) is widely used with STSG. CGDerm Matrix(®), which was recently developed, is a novel reprocessed micronized ADM (RMADM). In this study, outcomes of the combined application of RMADM and STSG on full-thickness wounds were analyzed. METHODS: Forty-one patients with full-thickness skin defects due to trauma, scar contracture release, and diabetic foot ulcers, who underwent STSGs, from January 2021 to July 2021, were retrospectively reviewed. The primary outcome of interest was skin loss rate, which was measured 14 days after surgery. RESULTS: The most common cause of skin defect was trauma (36 patients), diabetic foot (2 patients), scar contracture release (2 patients), and malignancy (1 patient). The average defect size was 109.6 cm(2) (range, 8–450 cm(2)). The average skin loss rate was 9.1%, showing a graft take rate of > 90%. CONCLUSION: The use of combined RMADM and STSG in full-thickness wound reconstruction provides stable and acceptable outcomes. The newly developed ADM can be a promising option in wound reconstruction. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12893-022-01801-x. |
format | Online Article Text |
id | pubmed-9555098 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-95550982022-10-13 Efficacy of split-thickness skin graft combined with novel sheet-type reprocessed micronized acellular dermal matrix Hahn, Hyung Min Jeong, Yon Soo Lee, Il Jae Kim, Min Ji Lim, Hyoseob BMC Surg Research BACKGROUND: Autologous split-thickness skin grafts (STSGs) remain the mainstay for treatment of large skin defects. Despite its many advantages, there exist critical disadvantages such as unfavorable scar and graft contracture. In addition, it cannot be used when structures such as tendons and bones are exposed. To overcome these limitations, acellular dermal matrix (ADM) is widely used with STSG. CGDerm Matrix(®), which was recently developed, is a novel reprocessed micronized ADM (RMADM). In this study, outcomes of the combined application of RMADM and STSG on full-thickness wounds were analyzed. METHODS: Forty-one patients with full-thickness skin defects due to trauma, scar contracture release, and diabetic foot ulcers, who underwent STSGs, from January 2021 to July 2021, were retrospectively reviewed. The primary outcome of interest was skin loss rate, which was measured 14 days after surgery. RESULTS: The most common cause of skin defect was trauma (36 patients), diabetic foot (2 patients), scar contracture release (2 patients), and malignancy (1 patient). The average defect size was 109.6 cm(2) (range, 8–450 cm(2)). The average skin loss rate was 9.1%, showing a graft take rate of > 90%. CONCLUSION: The use of combined RMADM and STSG in full-thickness wound reconstruction provides stable and acceptable outcomes. The newly developed ADM can be a promising option in wound reconstruction. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12893-022-01801-x. BioMed Central 2022-10-11 /pmc/articles/PMC9555098/ /pubmed/36221130 http://dx.doi.org/10.1186/s12893-022-01801-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Hahn, Hyung Min Jeong, Yon Soo Lee, Il Jae Kim, Min Ji Lim, Hyoseob Efficacy of split-thickness skin graft combined with novel sheet-type reprocessed micronized acellular dermal matrix |
title | Efficacy of split-thickness skin graft combined with novel sheet-type reprocessed micronized acellular dermal matrix |
title_full | Efficacy of split-thickness skin graft combined with novel sheet-type reprocessed micronized acellular dermal matrix |
title_fullStr | Efficacy of split-thickness skin graft combined with novel sheet-type reprocessed micronized acellular dermal matrix |
title_full_unstemmed | Efficacy of split-thickness skin graft combined with novel sheet-type reprocessed micronized acellular dermal matrix |
title_short | Efficacy of split-thickness skin graft combined with novel sheet-type reprocessed micronized acellular dermal matrix |
title_sort | efficacy of split-thickness skin graft combined with novel sheet-type reprocessed micronized acellular dermal matrix |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555098/ https://www.ncbi.nlm.nih.gov/pubmed/36221130 http://dx.doi.org/10.1186/s12893-022-01801-x |
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