Exosomes: mediators regulating the phenotypic transition of vascular smooth muscle cells in atherosclerosis

Cardiovascular disease is one of the leading causes of human mortality worldwide, mainly due to atherosclerosis (AS), and the phenotypic transition of vascular smooth muscle cells (VSMCs) is a key event in the development of AS. Exosomes contain a variety of specific nucleic acids and proteins that...

Descripción completa

Detalles Bibliográficos
Autores principales: Yao, Jiali, Cai, Linqian, Chen, Yingrui, Zhang, Jie, Zhuang, Wenwen, Liang, Jingyan, Li, Hongliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555104/
https://www.ncbi.nlm.nih.gov/pubmed/36221105
http://dx.doi.org/10.1186/s12964-022-00949-6
Descripción
Sumario:Cardiovascular disease is one of the leading causes of human mortality worldwide, mainly due to atherosclerosis (AS), and the phenotypic transition of vascular smooth muscle cells (VSMCs) is a key event in the development of AS. Exosomes contain a variety of specific nucleic acids and proteins that mediate intercellular communication. The role of exosomes in AS has attracted attention. This review uses the VSMC phenotypic transition in AS as the entry point, introduces the effect of exosomes on AS from different perspectives, and discusses the status quo, deficiencies, and potential future directions in this field to provide new ideas for clinical research and treatment of AS. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-022-00949-6.

Ejemplares similares