Exosomes: mediators regulating the phenotypic transition of vascular smooth muscle cells in atherosclerosis

Cardiovascular disease is one of the leading causes of human mortality worldwide, mainly due to atherosclerosis (AS), and the phenotypic transition of vascular smooth muscle cells (VSMCs) is a key event in the development of AS. Exosomes contain a variety of specific nucleic acids and proteins that...

Descripción completa

Detalles Bibliográficos
Autores principales: Yao, Jiali, Cai, Linqian, Chen, Yingrui, Zhang, Jie, Zhuang, Wenwen, Liang, Jingyan, Li, Hongliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555104/
https://www.ncbi.nlm.nih.gov/pubmed/36221105
http://dx.doi.org/10.1186/s12964-022-00949-6
_version_ 1784806842056048640
author Yao, Jiali
Cai, Linqian
Chen, Yingrui
Zhang, Jie
Zhuang, Wenwen
Liang, Jingyan
Li, Hongliang
author_facet Yao, Jiali
Cai, Linqian
Chen, Yingrui
Zhang, Jie
Zhuang, Wenwen
Liang, Jingyan
Li, Hongliang
author_sort Yao, Jiali
collection PubMed
description Cardiovascular disease is one of the leading causes of human mortality worldwide, mainly due to atherosclerosis (AS), and the phenotypic transition of vascular smooth muscle cells (VSMCs) is a key event in the development of AS. Exosomes contain a variety of specific nucleic acids and proteins that mediate intercellular communication. The role of exosomes in AS has attracted attention. This review uses the VSMC phenotypic transition in AS as the entry point, introduces the effect of exosomes on AS from different perspectives, and discusses the status quo, deficiencies, and potential future directions in this field to provide new ideas for clinical research and treatment of AS. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-022-00949-6.
format Online
Article
Text
id pubmed-9555104
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-95551042022-10-13 Exosomes: mediators regulating the phenotypic transition of vascular smooth muscle cells in atherosclerosis Yao, Jiali Cai, Linqian Chen, Yingrui Zhang, Jie Zhuang, Wenwen Liang, Jingyan Li, Hongliang Cell Commun Signal Review Cardiovascular disease is one of the leading causes of human mortality worldwide, mainly due to atherosclerosis (AS), and the phenotypic transition of vascular smooth muscle cells (VSMCs) is a key event in the development of AS. Exosomes contain a variety of specific nucleic acids and proteins that mediate intercellular communication. The role of exosomes in AS has attracted attention. This review uses the VSMC phenotypic transition in AS as the entry point, introduces the effect of exosomes on AS from different perspectives, and discusses the status quo, deficiencies, and potential future directions in this field to provide new ideas for clinical research and treatment of AS. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-022-00949-6. BioMed Central 2022-10-11 /pmc/articles/PMC9555104/ /pubmed/36221105 http://dx.doi.org/10.1186/s12964-022-00949-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Yao, Jiali
Cai, Linqian
Chen, Yingrui
Zhang, Jie
Zhuang, Wenwen
Liang, Jingyan
Li, Hongliang
Exosomes: mediators regulating the phenotypic transition of vascular smooth muscle cells in atherosclerosis
title Exosomes: mediators regulating the phenotypic transition of vascular smooth muscle cells in atherosclerosis
title_full Exosomes: mediators regulating the phenotypic transition of vascular smooth muscle cells in atherosclerosis
title_fullStr Exosomes: mediators regulating the phenotypic transition of vascular smooth muscle cells in atherosclerosis
title_full_unstemmed Exosomes: mediators regulating the phenotypic transition of vascular smooth muscle cells in atherosclerosis
title_short Exosomes: mediators regulating the phenotypic transition of vascular smooth muscle cells in atherosclerosis
title_sort exosomes: mediators regulating the phenotypic transition of vascular smooth muscle cells in atherosclerosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555104/
https://www.ncbi.nlm.nih.gov/pubmed/36221105
http://dx.doi.org/10.1186/s12964-022-00949-6
work_keys_str_mv AT yaojiali exosomesmediatorsregulatingthephenotypictransitionofvascularsmoothmusclecellsinatherosclerosis
AT cailinqian exosomesmediatorsregulatingthephenotypictransitionofvascularsmoothmusclecellsinatherosclerosis
AT chenyingrui exosomesmediatorsregulatingthephenotypictransitionofvascularsmoothmusclecellsinatherosclerosis
AT zhangjie exosomesmediatorsregulatingthephenotypictransitionofvascularsmoothmusclecellsinatherosclerosis
AT zhuangwenwen exosomesmediatorsregulatingthephenotypictransitionofvascularsmoothmusclecellsinatherosclerosis
AT liangjingyan exosomesmediatorsregulatingthephenotypictransitionofvascularsmoothmusclecellsinatherosclerosis
AT lihongliang exosomesmediatorsregulatingthephenotypictransitionofvascularsmoothmusclecellsinatherosclerosis

Ejemplares similares