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Periostin: biology and function in cancer
Periostin (POSTN), a member of the matricellular protein family, is a secreted adhesion-related protein produced in the periosteum and periodontal ligaments. Matricellular proteins are a nonstructural family of extracellular matrix (ECM) proteins that regulate a wide range of biological processes in...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555118/ https://www.ncbi.nlm.nih.gov/pubmed/36224629 http://dx.doi.org/10.1186/s12935-022-02714-8 |
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author | Dorafshan, Shima Razmi, Mahdieh Safaei, Sadegh Gentilin, Erica Madjd, Zahra Ghods, Roya |
author_facet | Dorafshan, Shima Razmi, Mahdieh Safaei, Sadegh Gentilin, Erica Madjd, Zahra Ghods, Roya |
author_sort | Dorafshan, Shima |
collection | PubMed |
description | Periostin (POSTN), a member of the matricellular protein family, is a secreted adhesion-related protein produced in the periosteum and periodontal ligaments. Matricellular proteins are a nonstructural family of extracellular matrix (ECM) proteins that regulate a wide range of biological processes in both normal and pathological conditions. Recent studies have demonstrated the key roles of these ECM proteins in the tumor microenvironment. Furthermore, periostin is an essential regulator of bone and tooth formation and maintenance, as well as cardiac development. Also, periostin interacts with multiple cell-surface receptors, especially integrins, and triggers signals that promote tumor growth. According to recent studies, these signals are implicated in cancer cell survival, epithelial-mesenchymal transition (EMT), invasion, and metastasis. In this review, we will summarize the most current data regarding periostin, its structure and isoforms, expressions, functions, and regulation in normal and cancerous tissues. Emphasis is placed on its association with cancer progression, and also future potential for periostin-targeted therapeutic approaches will be explored. |
format | Online Article Text |
id | pubmed-9555118 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-95551182022-10-13 Periostin: biology and function in cancer Dorafshan, Shima Razmi, Mahdieh Safaei, Sadegh Gentilin, Erica Madjd, Zahra Ghods, Roya Cancer Cell Int Review Periostin (POSTN), a member of the matricellular protein family, is a secreted adhesion-related protein produced in the periosteum and periodontal ligaments. Matricellular proteins are a nonstructural family of extracellular matrix (ECM) proteins that regulate a wide range of biological processes in both normal and pathological conditions. Recent studies have demonstrated the key roles of these ECM proteins in the tumor microenvironment. Furthermore, periostin is an essential regulator of bone and tooth formation and maintenance, as well as cardiac development. Also, periostin interacts with multiple cell-surface receptors, especially integrins, and triggers signals that promote tumor growth. According to recent studies, these signals are implicated in cancer cell survival, epithelial-mesenchymal transition (EMT), invasion, and metastasis. In this review, we will summarize the most current data regarding periostin, its structure and isoforms, expressions, functions, and regulation in normal and cancerous tissues. Emphasis is placed on its association with cancer progression, and also future potential for periostin-targeted therapeutic approaches will be explored. BioMed Central 2022-10-12 /pmc/articles/PMC9555118/ /pubmed/36224629 http://dx.doi.org/10.1186/s12935-022-02714-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Dorafshan, Shima Razmi, Mahdieh Safaei, Sadegh Gentilin, Erica Madjd, Zahra Ghods, Roya Periostin: biology and function in cancer |
title | Periostin: biology and function in cancer |
title_full | Periostin: biology and function in cancer |
title_fullStr | Periostin: biology and function in cancer |
title_full_unstemmed | Periostin: biology and function in cancer |
title_short | Periostin: biology and function in cancer |
title_sort | periostin: biology and function in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555118/ https://www.ncbi.nlm.nih.gov/pubmed/36224629 http://dx.doi.org/10.1186/s12935-022-02714-8 |
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