Breast Cancer after Radiation Therapy in a Patient with Li-Fraumeni Syndrome: A Case Report

Li-Fraumeni syndrome (LFS) is an inherited autosomal-dominant tumor-predisposition disorder caused by germline mutations in the TP53 tumor suppressor gene. Since patients with LFS are likely to develop therapy-related cancers, radiation therapy should be avoided if breast cancer is found in these in...

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Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Radiology 2022
Materias:
Breast Imaging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555176/
https://www.ncbi.nlm.nih.gov/pubmed/36237363
http://dx.doi.org/10.3348/jksr.2021.0045
Descripción
Sumario:Li-Fraumeni syndrome (LFS) is an inherited autosomal-dominant tumor-predisposition disorder caused by germline mutations in the TP53 tumor suppressor gene. Since patients with LFS are likely to develop therapy-related cancers, radiation therapy should be avoided if breast cancer is found in these individuals. Herein, we present a case of secondary breast cancer in an LFS patient after radiation and chemotherapy for the first diagnosed breast sarcoma.

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