Breast Cancer after Radiation Therapy in a Patient with Li-Fraumeni Syndrome: A Case Report

Li-Fraumeni syndrome (LFS) is an inherited autosomal-dominant tumor-predisposition disorder caused by germline mutations in the TP53 tumor suppressor gene. Since patients with LFS are likely to develop therapy-related cancers, radiation therapy should be avoided if breast cancer is found in these in...

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Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Radiology 2022
Materias:
Breast Imaging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555176/
https://www.ncbi.nlm.nih.gov/pubmed/36237363
http://dx.doi.org/10.3348/jksr.2021.0045
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description Li-Fraumeni syndrome (LFS) is an inherited autosomal-dominant tumor-predisposition disorder caused by germline mutations in the TP53 tumor suppressor gene. Since patients with LFS are likely to develop therapy-related cancers, radiation therapy should be avoided if breast cancer is found in these individuals. Herein, we present a case of secondary breast cancer in an LFS patient after radiation and chemotherapy for the first diagnosed breast sarcoma.
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spelling pubmed-95551762022-10-12 Breast Cancer after Radiation Therapy in a Patient with Li-Fraumeni Syndrome: A Case Report Taehan Yongsang Uihakhoe Chi Breast Imaging Li-Fraumeni syndrome (LFS) is an inherited autosomal-dominant tumor-predisposition disorder caused by germline mutations in the TP53 tumor suppressor gene. Since patients with LFS are likely to develop therapy-related cancers, radiation therapy should be avoided if breast cancer is found in these individuals. Herein, we present a case of secondary breast cancer in an LFS patient after radiation and chemotherapy for the first diagnosed breast sarcoma. The Korean Society of Radiology 2022-01 2021-10-18 /pmc/articles/PMC9555176/ /pubmed/36237363 http://dx.doi.org/10.3348/jksr.2021.0045 Text en Copyrights © 2022 The Korean Society of Radiology https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Breast Imaging
Breast Cancer after Radiation Therapy in a Patient with Li-Fraumeni Syndrome: A Case Report
title Breast Cancer after Radiation Therapy in a Patient with Li-Fraumeni Syndrome: A Case Report
title_full Breast Cancer after Radiation Therapy in a Patient with Li-Fraumeni Syndrome: A Case Report
title_fullStr Breast Cancer after Radiation Therapy in a Patient with Li-Fraumeni Syndrome: A Case Report
title_full_unstemmed Breast Cancer after Radiation Therapy in a Patient with Li-Fraumeni Syndrome: A Case Report
title_short Breast Cancer after Radiation Therapy in a Patient with Li-Fraumeni Syndrome: A Case Report
title_sort breast cancer after radiation therapy in a patient with li-fraumeni syndrome: a case report
topic Breast Imaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555176/
https://www.ncbi.nlm.nih.gov/pubmed/36237363
http://dx.doi.org/10.3348/jksr.2021.0045
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