Clinical significance of neutrophil extracellular traps biomarkers in thrombosis

Neutrophil extracellular traps (NETs) may be associated with the development of thrombosis. Experimental studies have confirmed the presence of NETs in thrombi specimens and potential role of NETs in the mechanisms of thrombosis. Clinical studies also have demonstrated significant changes in the lev...

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Autores principales: Xu, Xiangbo, Wu, Yuting, Xu, Shixue, Yin, Yue, Ageno, Walter, De Stefano, Valerio, Zhao, Qingchun, Qi, Xingshun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555260/
https://www.ncbi.nlm.nih.gov/pubmed/36224604
http://dx.doi.org/10.1186/s12959-022-00421-y
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author Xu, Xiangbo
Wu, Yuting
Xu, Shixue
Yin, Yue
Ageno, Walter
De Stefano, Valerio
Zhao, Qingchun
Qi, Xingshun
author_facet Xu, Xiangbo
Wu, Yuting
Xu, Shixue
Yin, Yue
Ageno, Walter
De Stefano, Valerio
Zhao, Qingchun
Qi, Xingshun
author_sort Xu, Xiangbo
collection PubMed
description Neutrophil extracellular traps (NETs) may be associated with the development of thrombosis. Experimental studies have confirmed the presence of NETs in thrombi specimens and potential role of NETs in the mechanisms of thrombosis. Clinical studies also have demonstrated significant changes in the levels of serum or plasma NETs biomarkers, such as citrullinated histones, myeloperoxidase, neutrophil elastase, nucleosomes, DNA, and their complexes in patients with thrombosis. This paper aims to comprehensively review the currently available evidence regarding the change in the levels of NETs biomarkers in patients with thrombosis, summarize the role of NETs and its biomarkers in the development and prognostic assessment of venous thromboembolism, coronary artery diseases, ischemic stroke, cancer-associated thromboembolism, and coronavirus disease 2019-associated thromboembolism, explore the potential therapeutic implications of NETs, and further discuss the shortcomings of existing NETs biomarkers in serum and plasma and their detection methods.
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spelling pubmed-95552602022-10-12 Clinical significance of neutrophil extracellular traps biomarkers in thrombosis Xu, Xiangbo Wu, Yuting Xu, Shixue Yin, Yue Ageno, Walter De Stefano, Valerio Zhao, Qingchun Qi, Xingshun Thromb J Review Neutrophil extracellular traps (NETs) may be associated with the development of thrombosis. Experimental studies have confirmed the presence of NETs in thrombi specimens and potential role of NETs in the mechanisms of thrombosis. Clinical studies also have demonstrated significant changes in the levels of serum or plasma NETs biomarkers, such as citrullinated histones, myeloperoxidase, neutrophil elastase, nucleosomes, DNA, and their complexes in patients with thrombosis. This paper aims to comprehensively review the currently available evidence regarding the change in the levels of NETs biomarkers in patients with thrombosis, summarize the role of NETs and its biomarkers in the development and prognostic assessment of venous thromboembolism, coronary artery diseases, ischemic stroke, cancer-associated thromboembolism, and coronavirus disease 2019-associated thromboembolism, explore the potential therapeutic implications of NETs, and further discuss the shortcomings of existing NETs biomarkers in serum and plasma and their detection methods. BioMed Central 2022-10-12 /pmc/articles/PMC9555260/ /pubmed/36224604 http://dx.doi.org/10.1186/s12959-022-00421-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Xu, Xiangbo
Wu, Yuting
Xu, Shixue
Yin, Yue
Ageno, Walter
De Stefano, Valerio
Zhao, Qingchun
Qi, Xingshun
Clinical significance of neutrophil extracellular traps biomarkers in thrombosis
title Clinical significance of neutrophil extracellular traps biomarkers in thrombosis
title_full Clinical significance of neutrophil extracellular traps biomarkers in thrombosis
title_fullStr Clinical significance of neutrophil extracellular traps biomarkers in thrombosis
title_full_unstemmed Clinical significance of neutrophil extracellular traps biomarkers in thrombosis
title_short Clinical significance of neutrophil extracellular traps biomarkers in thrombosis
title_sort clinical significance of neutrophil extracellular traps biomarkers in thrombosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555260/
https://www.ncbi.nlm.nih.gov/pubmed/36224604
http://dx.doi.org/10.1186/s12959-022-00421-y
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