Second window ICG predicts postoperative MRI gadolinium enhancement in high grade gliomas and brain metastases

A prospective trial evaluating the utility of second window indocyanine green (SWIG) in predicting postoperative MRI gadolinium enhancement was performed on high-grade gliomas (HGGs) and brain metastases. Compared to white light alone, SWIG demonstrated a higher sensitivity, negative predictive valu...

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Detalles Bibliográficos
Autores principales: Karsalia, Ritesh, Cheng, Nina H., Teng, Clare W., Cho, Steve S., Harmsen, Stefan, Lee, John Y. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association of Neurological Surgeons 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555347/
https://www.ncbi.nlm.nih.gov/pubmed/36284582
http://dx.doi.org/10.3171/2021.10.FOCVID21204
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author Karsalia, Ritesh
Cheng, Nina H.
Teng, Clare W.
Cho, Steve S.
Harmsen, Stefan
Lee, John Y. K.
author_facet Karsalia, Ritesh
Cheng, Nina H.
Teng, Clare W.
Cho, Steve S.
Harmsen, Stefan
Lee, John Y. K.
author_sort Karsalia, Ritesh
collection PubMed
description A prospective trial evaluating the utility of second window indocyanine green (SWIG) in predicting postoperative MRI gadolinium enhancement was performed on high-grade gliomas (HGGs) and brain metastases. Compared to white light alone, SWIG demonstrated a higher sensitivity, negative predictive value, and accuracy in predicting residual neoplasm on MRI. The specificity of SWIG for predicting MRI enhancement was higher in HGGs than brain metastases. Clinically, near-infrared (NIR) imaging was better able to predict tumor recurrence than postoperative MRI. These results illustrate how SWIG is able to take advantage of gadolinium-like distribution properties to extravasate into the tumor microenvironment, enabling guidance in surgical resection. The video can be found here: https://stream.cadmore.media/r10.3171/2021.10.FOCVID21204
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spelling pubmed-95553472022-10-24 Second window ICG predicts postoperative MRI gadolinium enhancement in high grade gliomas and brain metastases Karsalia, Ritesh Cheng, Nina H. Teng, Clare W. Cho, Steve S. Harmsen, Stefan Lee, John Y. K. Neurosurg Focus Video Article A prospective trial evaluating the utility of second window indocyanine green (SWIG) in predicting postoperative MRI gadolinium enhancement was performed on high-grade gliomas (HGGs) and brain metastases. Compared to white light alone, SWIG demonstrated a higher sensitivity, negative predictive value, and accuracy in predicting residual neoplasm on MRI. The specificity of SWIG for predicting MRI enhancement was higher in HGGs than brain metastases. Clinically, near-infrared (NIR) imaging was better able to predict tumor recurrence than postoperative MRI. These results illustrate how SWIG is able to take advantage of gadolinium-like distribution properties to extravasate into the tumor microenvironment, enabling guidance in surgical resection. The video can be found here: https://stream.cadmore.media/r10.3171/2021.10.FOCVID21204 American Association of Neurological Surgeons 2022-01-01 /pmc/articles/PMC9555347/ /pubmed/36284582 http://dx.doi.org/10.3171/2021.10.FOCVID21204 Text en © 2022, The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the CC BY license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Karsalia, Ritesh
Cheng, Nina H.
Teng, Clare W.
Cho, Steve S.
Harmsen, Stefan
Lee, John Y. K.
Second window ICG predicts postoperative MRI gadolinium enhancement in high grade gliomas and brain metastases
title Second window ICG predicts postoperative MRI gadolinium enhancement in high grade gliomas and brain metastases
title_full Second window ICG predicts postoperative MRI gadolinium enhancement in high grade gliomas and brain metastases
title_fullStr Second window ICG predicts postoperative MRI gadolinium enhancement in high grade gliomas and brain metastases
title_full_unstemmed Second window ICG predicts postoperative MRI gadolinium enhancement in high grade gliomas and brain metastases
title_short Second window ICG predicts postoperative MRI gadolinium enhancement in high grade gliomas and brain metastases
title_sort second window icg predicts postoperative mri gadolinium enhancement in high grade gliomas and brain metastases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555347/
https://www.ncbi.nlm.nih.gov/pubmed/36284582
http://dx.doi.org/10.3171/2021.10.FOCVID21204
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