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Investigation of the association between the antibody responses to neurotropic viruses and dementia outcomes in the UK Biobank
The causes that trigger the onset of dementia are still unknown. Recently there has been an increasing interest in the possible role of infectious agents in the brain in the pathogenesis of this condition. Amongst the viruses, members of the Herpesviridae family, namely herpes simplex virus-1 (HSV1)...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555633/ https://www.ncbi.nlm.nih.gov/pubmed/36223333 http://dx.doi.org/10.1371/journal.pone.0274872 |
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author | Mekli, Krisztina Lophatananon, Artitaya Cant, Rachel Burns, Alistair Dobson, Curtis B. Itzhaki, Ruth F. Muir, Kenneth R. |
author_facet | Mekli, Krisztina Lophatananon, Artitaya Cant, Rachel Burns, Alistair Dobson, Curtis B. Itzhaki, Ruth F. Muir, Kenneth R. |
author_sort | Mekli, Krisztina |
collection | PubMed |
description | The causes that trigger the onset of dementia are still unknown. Recently there has been an increasing interest in the possible role of infectious agents in the brain in the pathogenesis of this condition. Amongst the viruses, members of the Herpesviridae family, namely herpes simplex virus-1 (HSV1), cytomegalovirus (CMV), human herpesvirus-6 (HHV6), human herpesvirus-7 (HHV7) and varicella zoster virus (VZV) have been suggested as potential causes of the disease. However, the relative importance of these and other viruses in contributing to dementia remains unclear. We evaluated the association between seropositivity status of all viruses available in a large, population-based dataset (the UK Biobank) and dementia risk in an unbiased way. Of the 15 viruses investigated, our results showed a statistically significant increase of dementia risk associated only with HSV1 seropositivity (OR 2.14, 95% C.I. 1.21–3.81). However, by combining the data we found that seropositivity for 4 viruses (HSV1, HHV6, HHV7 and VZV) also significantly increases the risk of dementia (OR = 2.37, 95% C.I. 1.43–3.92). These four viruses have been described previously as neurotropic viruses. Our results provide support for a role for neurotropic viruses in the pathology of dementia. |
format | Online Article Text |
id | pubmed-9555633 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-95556332022-10-13 Investigation of the association between the antibody responses to neurotropic viruses and dementia outcomes in the UK Biobank Mekli, Krisztina Lophatananon, Artitaya Cant, Rachel Burns, Alistair Dobson, Curtis B. Itzhaki, Ruth F. Muir, Kenneth R. PLoS One Research Article The causes that trigger the onset of dementia are still unknown. Recently there has been an increasing interest in the possible role of infectious agents in the brain in the pathogenesis of this condition. Amongst the viruses, members of the Herpesviridae family, namely herpes simplex virus-1 (HSV1), cytomegalovirus (CMV), human herpesvirus-6 (HHV6), human herpesvirus-7 (HHV7) and varicella zoster virus (VZV) have been suggested as potential causes of the disease. However, the relative importance of these and other viruses in contributing to dementia remains unclear. We evaluated the association between seropositivity status of all viruses available in a large, population-based dataset (the UK Biobank) and dementia risk in an unbiased way. Of the 15 viruses investigated, our results showed a statistically significant increase of dementia risk associated only with HSV1 seropositivity (OR 2.14, 95% C.I. 1.21–3.81). However, by combining the data we found that seropositivity for 4 viruses (HSV1, HHV6, HHV7 and VZV) also significantly increases the risk of dementia (OR = 2.37, 95% C.I. 1.43–3.92). These four viruses have been described previously as neurotropic viruses. Our results provide support for a role for neurotropic viruses in the pathology of dementia. Public Library of Science 2022-10-12 /pmc/articles/PMC9555633/ /pubmed/36223333 http://dx.doi.org/10.1371/journal.pone.0274872 Text en © 2022 Mekli et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Mekli, Krisztina Lophatananon, Artitaya Cant, Rachel Burns, Alistair Dobson, Curtis B. Itzhaki, Ruth F. Muir, Kenneth R. Investigation of the association between the antibody responses to neurotropic viruses and dementia outcomes in the UK Biobank |
title | Investigation of the association between the antibody responses to neurotropic viruses and dementia outcomes in the UK Biobank |
title_full | Investigation of the association between the antibody responses to neurotropic viruses and dementia outcomes in the UK Biobank |
title_fullStr | Investigation of the association between the antibody responses to neurotropic viruses and dementia outcomes in the UK Biobank |
title_full_unstemmed | Investigation of the association between the antibody responses to neurotropic viruses and dementia outcomes in the UK Biobank |
title_short | Investigation of the association between the antibody responses to neurotropic viruses and dementia outcomes in the UK Biobank |
title_sort | investigation of the association between the antibody responses to neurotropic viruses and dementia outcomes in the uk biobank |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555633/ https://www.ncbi.nlm.nih.gov/pubmed/36223333 http://dx.doi.org/10.1371/journal.pone.0274872 |
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