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Investigation of the association between the antibody responses to neurotropic viruses and dementia outcomes in the UK Biobank

The causes that trigger the onset of dementia are still unknown. Recently there has been an increasing interest in the possible role of infectious agents in the brain in the pathogenesis of this condition. Amongst the viruses, members of the Herpesviridae family, namely herpes simplex virus-1 (HSV1)...

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Autores principales: Mekli, Krisztina, Lophatananon, Artitaya, Cant, Rachel, Burns, Alistair, Dobson, Curtis B., Itzhaki, Ruth F., Muir, Kenneth R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555633/
https://www.ncbi.nlm.nih.gov/pubmed/36223333
http://dx.doi.org/10.1371/journal.pone.0274872
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author Mekli, Krisztina
Lophatananon, Artitaya
Cant, Rachel
Burns, Alistair
Dobson, Curtis B.
Itzhaki, Ruth F.
Muir, Kenneth R.
author_facet Mekli, Krisztina
Lophatananon, Artitaya
Cant, Rachel
Burns, Alistair
Dobson, Curtis B.
Itzhaki, Ruth F.
Muir, Kenneth R.
author_sort Mekli, Krisztina
collection PubMed
description The causes that trigger the onset of dementia are still unknown. Recently there has been an increasing interest in the possible role of infectious agents in the brain in the pathogenesis of this condition. Amongst the viruses, members of the Herpesviridae family, namely herpes simplex virus-1 (HSV1), cytomegalovirus (CMV), human herpesvirus-6 (HHV6), human herpesvirus-7 (HHV7) and varicella zoster virus (VZV) have been suggested as potential causes of the disease. However, the relative importance of these and other viruses in contributing to dementia remains unclear. We evaluated the association between seropositivity status of all viruses available in a large, population-based dataset (the UK Biobank) and dementia risk in an unbiased way. Of the 15 viruses investigated, our results showed a statistically significant increase of dementia risk associated only with HSV1 seropositivity (OR 2.14, 95% C.I. 1.21–3.81). However, by combining the data we found that seropositivity for 4 viruses (HSV1, HHV6, HHV7 and VZV) also significantly increases the risk of dementia (OR = 2.37, 95% C.I. 1.43–3.92). These four viruses have been described previously as neurotropic viruses. Our results provide support for a role for neurotropic viruses in the pathology of dementia.
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spelling pubmed-95556332022-10-13 Investigation of the association between the antibody responses to neurotropic viruses and dementia outcomes in the UK Biobank Mekli, Krisztina Lophatananon, Artitaya Cant, Rachel Burns, Alistair Dobson, Curtis B. Itzhaki, Ruth F. Muir, Kenneth R. PLoS One Research Article The causes that trigger the onset of dementia are still unknown. Recently there has been an increasing interest in the possible role of infectious agents in the brain in the pathogenesis of this condition. Amongst the viruses, members of the Herpesviridae family, namely herpes simplex virus-1 (HSV1), cytomegalovirus (CMV), human herpesvirus-6 (HHV6), human herpesvirus-7 (HHV7) and varicella zoster virus (VZV) have been suggested as potential causes of the disease. However, the relative importance of these and other viruses in contributing to dementia remains unclear. We evaluated the association between seropositivity status of all viruses available in a large, population-based dataset (the UK Biobank) and dementia risk in an unbiased way. Of the 15 viruses investigated, our results showed a statistically significant increase of dementia risk associated only with HSV1 seropositivity (OR 2.14, 95% C.I. 1.21–3.81). However, by combining the data we found that seropositivity for 4 viruses (HSV1, HHV6, HHV7 and VZV) also significantly increases the risk of dementia (OR = 2.37, 95% C.I. 1.43–3.92). These four viruses have been described previously as neurotropic viruses. Our results provide support for a role for neurotropic viruses in the pathology of dementia. Public Library of Science 2022-10-12 /pmc/articles/PMC9555633/ /pubmed/36223333 http://dx.doi.org/10.1371/journal.pone.0274872 Text en © 2022 Mekli et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Mekli, Krisztina
Lophatananon, Artitaya
Cant, Rachel
Burns, Alistair
Dobson, Curtis B.
Itzhaki, Ruth F.
Muir, Kenneth R.
Investigation of the association between the antibody responses to neurotropic viruses and dementia outcomes in the UK Biobank
title Investigation of the association between the antibody responses to neurotropic viruses and dementia outcomes in the UK Biobank
title_full Investigation of the association between the antibody responses to neurotropic viruses and dementia outcomes in the UK Biobank
title_fullStr Investigation of the association between the antibody responses to neurotropic viruses and dementia outcomes in the UK Biobank
title_full_unstemmed Investigation of the association between the antibody responses to neurotropic viruses and dementia outcomes in the UK Biobank
title_short Investigation of the association between the antibody responses to neurotropic viruses and dementia outcomes in the UK Biobank
title_sort investigation of the association between the antibody responses to neurotropic viruses and dementia outcomes in the uk biobank
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555633/
https://www.ncbi.nlm.nih.gov/pubmed/36223333
http://dx.doi.org/10.1371/journal.pone.0274872
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