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Lipid droplet turnover at the lysosome inhibits growth of hepatocellular carcinoma in a BNIP3-dependent manner

Hepatic steatosis is a major etiological factor in hepatocellular carcinoma (HCC), but factors causing lipid accumulation leading to HCC are not understood. We identify BNIP3 (a mitochondrial cargo receptor) as an HCC suppressor that mitigates against lipid accumulation to attenuate tumor cell growt...

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Detalles Bibliográficos
Autores principales:	Berardi, Damian E., Bock-Hughes, Althea, Terry, Alexander R., Drake, Lauren E., Bozek, Grazyna, Macleod, Kay F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555787/ https://www.ncbi.nlm.nih.gov/pubmed/36223464 http://dx.doi.org/10.1126/sciadv.abo2510

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