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Neural signatures of auditory hypersensitivity following acoustic trauma
Neurons in sensory cortex exhibit a remarkable capacity to maintain stable firing rates despite large fluctuations in afferent activity levels. However, sudden peripheral deafferentation in adulthood can trigger an excessive, non-homeostatic cortical compensatory response that may underlie perceptua...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555866/ https://www.ncbi.nlm.nih.gov/pubmed/36111669 http://dx.doi.org/10.7554/eLife.80015 |
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author | McGill, Matthew Hight, Ariel E Watanabe, Yurika L Parthasarathy, Aravindakshan Cai, Dongqin Clayton, Kameron Hancock, Kenneth E Takesian, Anne Kujawa, Sharon G Polley, Daniel B |
author_facet | McGill, Matthew Hight, Ariel E Watanabe, Yurika L Parthasarathy, Aravindakshan Cai, Dongqin Clayton, Kameron Hancock, Kenneth E Takesian, Anne Kujawa, Sharon G Polley, Daniel B |
author_sort | McGill, Matthew |
collection | PubMed |
description | Neurons in sensory cortex exhibit a remarkable capacity to maintain stable firing rates despite large fluctuations in afferent activity levels. However, sudden peripheral deafferentation in adulthood can trigger an excessive, non-homeostatic cortical compensatory response that may underlie perceptual disorders including sensory hypersensitivity, phantom limb pain, and tinnitus. Here, we show that mice with noise-induced damage of the high-frequency cochlear base were behaviorally hypersensitive to spared mid-frequency tones and to direct optogenetic stimulation of auditory thalamocortical neurons. Chronic two-photon calcium imaging from ACtx pyramidal neurons (PyrNs) revealed an initial stage of spatially diffuse hyperactivity, hyper-correlation, and auditory hyperresponsivity that consolidated around deafferented map regions three or more days after acoustic trauma. Deafferented PyrN ensembles also displayed hypersensitive decoding of spared mid-frequency tones that mirrored behavioral hypersensitivity, suggesting that non-homeostatic regulation of cortical sound intensity coding following sensorineural loss may be an underlying source of auditory hypersensitivity. Excess cortical response gain after acoustic trauma was expressed heterogeneously among individual PyrNs, yet 40% of this variability could be accounted for by each cell’s baseline response properties prior to acoustic trauma. PyrNs with initially high spontaneous activity and gradual monotonic intensity growth functions were more likely to exhibit non-homeostatic excess gain after acoustic trauma. This suggests that while cortical gain changes are triggered by reduced bottom-up afferent input, their subsequent stabilization is also shaped by their local circuit milieu, where indicators of reduced inhibition can presage pathological hyperactivity following sensorineural hearing loss. |
format | Online Article Text |
id | pubmed-9555866 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-95558662022-10-13 Neural signatures of auditory hypersensitivity following acoustic trauma McGill, Matthew Hight, Ariel E Watanabe, Yurika L Parthasarathy, Aravindakshan Cai, Dongqin Clayton, Kameron Hancock, Kenneth E Takesian, Anne Kujawa, Sharon G Polley, Daniel B eLife Neuroscience Neurons in sensory cortex exhibit a remarkable capacity to maintain stable firing rates despite large fluctuations in afferent activity levels. However, sudden peripheral deafferentation in adulthood can trigger an excessive, non-homeostatic cortical compensatory response that may underlie perceptual disorders including sensory hypersensitivity, phantom limb pain, and tinnitus. Here, we show that mice with noise-induced damage of the high-frequency cochlear base were behaviorally hypersensitive to spared mid-frequency tones and to direct optogenetic stimulation of auditory thalamocortical neurons. Chronic two-photon calcium imaging from ACtx pyramidal neurons (PyrNs) revealed an initial stage of spatially diffuse hyperactivity, hyper-correlation, and auditory hyperresponsivity that consolidated around deafferented map regions three or more days after acoustic trauma. Deafferented PyrN ensembles also displayed hypersensitive decoding of spared mid-frequency tones that mirrored behavioral hypersensitivity, suggesting that non-homeostatic regulation of cortical sound intensity coding following sensorineural loss may be an underlying source of auditory hypersensitivity. Excess cortical response gain after acoustic trauma was expressed heterogeneously among individual PyrNs, yet 40% of this variability could be accounted for by each cell’s baseline response properties prior to acoustic trauma. PyrNs with initially high spontaneous activity and gradual monotonic intensity growth functions were more likely to exhibit non-homeostatic excess gain after acoustic trauma. This suggests that while cortical gain changes are triggered by reduced bottom-up afferent input, their subsequent stabilization is also shaped by their local circuit milieu, where indicators of reduced inhibition can presage pathological hyperactivity following sensorineural hearing loss. eLife Sciences Publications, Ltd 2022-09-16 /pmc/articles/PMC9555866/ /pubmed/36111669 http://dx.doi.org/10.7554/eLife.80015 Text en © 2022, McGill et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience McGill, Matthew Hight, Ariel E Watanabe, Yurika L Parthasarathy, Aravindakshan Cai, Dongqin Clayton, Kameron Hancock, Kenneth E Takesian, Anne Kujawa, Sharon G Polley, Daniel B Neural signatures of auditory hypersensitivity following acoustic trauma |
title | Neural signatures of auditory hypersensitivity following acoustic trauma |
title_full | Neural signatures of auditory hypersensitivity following acoustic trauma |
title_fullStr | Neural signatures of auditory hypersensitivity following acoustic trauma |
title_full_unstemmed | Neural signatures of auditory hypersensitivity following acoustic trauma |
title_short | Neural signatures of auditory hypersensitivity following acoustic trauma |
title_sort | neural signatures of auditory hypersensitivity following acoustic trauma |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555866/ https://www.ncbi.nlm.nih.gov/pubmed/36111669 http://dx.doi.org/10.7554/eLife.80015 |
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