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Relief of chronic pain associated with increase in midline frontal theta power

INTRODUCTION: There is a need to identify objective cortical electrophysiological correlates for pain relief that could potentially contribute to a better pain management. However, the field of developing brain biomarkers for pain relief is still largely underexplored. OBJECTIVES: The objective of t...

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Autores principales: Rustamov, Nabi, Wilson, Elizabeth A., Fogarty, Alexandra E., Crock, Lara W., Leuthardt, Eric C., Haroutounian, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555895/
https://www.ncbi.nlm.nih.gov/pubmed/36247110
http://dx.doi.org/10.1097/PR9.0000000000001040
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author Rustamov, Nabi
Wilson, Elizabeth A.
Fogarty, Alexandra E.
Crock, Lara W.
Leuthardt, Eric C.
Haroutounian, Simon
author_facet Rustamov, Nabi
Wilson, Elizabeth A.
Fogarty, Alexandra E.
Crock, Lara W.
Leuthardt, Eric C.
Haroutounian, Simon
author_sort Rustamov, Nabi
collection PubMed
description INTRODUCTION: There is a need to identify objective cortical electrophysiological correlates for pain relief that could potentially contribute to a better pain management. However, the field of developing brain biomarkers for pain relief is still largely underexplored. OBJECTIVES: The objective of this study was to investigate cortical electrophysiological correlates associated with relief from chronic pain. Those features of pain relief could serve as potential targets for novel therapeutic interventions to treat pain. METHODS: In 12 patients with chronic pain in the upper or lower extremity undergoing a clinically indicated nerve block procedure, brain activity was recorded by means of electroencephalogram before and 30 minutes after the nerve block procedure. To determine the specific cortical electrophysiological correlates of relief from chronic pain, 12 healthy participants undergoing cold-pressor test to induce experimental acute pain were used as a control group. The data were analyzed to characterize power spectral density patterns of pain relief and identify their source generators at cortical level. RESULTS: Chronic pain relief was associated with significant delta, theta, and alpha power increase at the frontal area. However, only midfrontal theta power increase showed significant positive correlation with magnitude of reduction in pain intensity. The sources of theta power rebound were located in the left dorsolateral prefrontal cortex (DLPFC) and midline frontal cortex. Furthermore, theta power increase in the midline frontal cortex was significantly higher with chronic vs acute pain relief. CONCLUSION: These findings may provide basis for targeting chronic pain relief via modulation of the midline frontal theta oscillations.
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spelling pubmed-95558952022-10-13 Relief of chronic pain associated with increase in midline frontal theta power Rustamov, Nabi Wilson, Elizabeth A. Fogarty, Alexandra E. Crock, Lara W. Leuthardt, Eric C. Haroutounian, Simon Pain Rep General Section INTRODUCTION: There is a need to identify objective cortical electrophysiological correlates for pain relief that could potentially contribute to a better pain management. However, the field of developing brain biomarkers for pain relief is still largely underexplored. OBJECTIVES: The objective of this study was to investigate cortical electrophysiological correlates associated with relief from chronic pain. Those features of pain relief could serve as potential targets for novel therapeutic interventions to treat pain. METHODS: In 12 patients with chronic pain in the upper or lower extremity undergoing a clinically indicated nerve block procedure, brain activity was recorded by means of electroencephalogram before and 30 minutes after the nerve block procedure. To determine the specific cortical electrophysiological correlates of relief from chronic pain, 12 healthy participants undergoing cold-pressor test to induce experimental acute pain were used as a control group. The data were analyzed to characterize power spectral density patterns of pain relief and identify their source generators at cortical level. RESULTS: Chronic pain relief was associated with significant delta, theta, and alpha power increase at the frontal area. However, only midfrontal theta power increase showed significant positive correlation with magnitude of reduction in pain intensity. The sources of theta power rebound were located in the left dorsolateral prefrontal cortex (DLPFC) and midline frontal cortex. Furthermore, theta power increase in the midline frontal cortex was significantly higher with chronic vs acute pain relief. CONCLUSION: These findings may provide basis for targeting chronic pain relief via modulation of the midline frontal theta oscillations. Wolters Kluwer 2022-10-10 /pmc/articles/PMC9555895/ /pubmed/36247110 http://dx.doi.org/10.1097/PR9.0000000000001040 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle General Section
Rustamov, Nabi
Wilson, Elizabeth A.
Fogarty, Alexandra E.
Crock, Lara W.
Leuthardt, Eric C.
Haroutounian, Simon
Relief of chronic pain associated with increase in midline frontal theta power
title Relief of chronic pain associated with increase in midline frontal theta power
title_full Relief of chronic pain associated with increase in midline frontal theta power
title_fullStr Relief of chronic pain associated with increase in midline frontal theta power
title_full_unstemmed Relief of chronic pain associated with increase in midline frontal theta power
title_short Relief of chronic pain associated with increase in midline frontal theta power
title_sort relief of chronic pain associated with increase in midline frontal theta power
topic General Section
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9555895/
https://www.ncbi.nlm.nih.gov/pubmed/36247110
http://dx.doi.org/10.1097/PR9.0000000000001040
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