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Development and characterization of type I interferon receptor knockout sheep: A model for viral immunology and reproductive signaling

Type I interferons (IFNs) initiate immune responses to viral infections. Their effects are mediated by the type I IFN receptor, IFNAR, comprised of two subunits: IFNAR1 and IFNAR2. One or both chains of the sheep IFNAR were disrupted in fetal fibroblast lines using CRISPR/Cas9 and 12 lambs were prod...

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Detalles Bibliográficos
Autores principales:	Davies, Christopher J., Fan, Zhiqiang, Morgado, Kira P., Liu, Ying, Regouski, Misha, Meng, Qinggang, Thomas, Aaron J., Yun, Sang-Im, Song, Byung-Hak, Frank, Jordan C., Perisse, Iuri V., Van Wettere, Arnaud, Lee, Young-Min, Polejaeva, Irina A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556006/ https://www.ncbi.nlm.nih.gov/pubmed/36246651 http://dx.doi.org/10.3389/fgene.2022.986316

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