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The Anti-inflammatory Effect of Chitosan Oligosaccharide on Heart Failure in Mice

Heart failure is currently one of the leading causes of death worldwide, and the inflammatory factors play an important role in its development. Chitosan oligosaccharide (COS), a low-molecular-weight form of chitosan, has many specific biological activities. In this study, COS effects on heart failu...

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Autores principales: Zhang, Yubiao, Wang, Yu, Liu, Yunen, Gong, Tianxing, Hou, Mingxiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556196/
https://www.ncbi.nlm.nih.gov/pubmed/36246979
http://dx.doi.org/10.1155/2022/8746530
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author Zhang, Yubiao
Wang, Yu
Liu, Yunen
Gong, Tianxing
Hou, Mingxiao
author_facet Zhang, Yubiao
Wang, Yu
Liu, Yunen
Gong, Tianxing
Hou, Mingxiao
author_sort Zhang, Yubiao
collection PubMed
description Heart failure is currently one of the leading causes of death worldwide, and the inflammatory factors play an important role in its development. Chitosan oligosaccharide (COS), a low-molecular-weight form of chitosan, has many specific biological activities. In this study, COS effects on heart failure were studied for the first time by performing transverse arch constriction (TAC) surgery in mice, as an animal model of heart failure. Our findings revealed that COS administration (in both 40 mg/kg and 80 mg/kg doses) significantly ameliorated TCA-induced left ventricular (LV) hypertrophy as well as the increase in lung and heart weight in mice, while improving TAC-induced LV dysfunction. Both doses effectively attenuated LV cardiomyocyte hypertrophy, while decreasing heart inflammation after heart failure in mice. In conclusion, our results indicated that the supplementation of COS in normal diet might be an effective way to prevent further myocardial tissue damage in patients suffering from heart failure.
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spelling pubmed-95561962022-10-13 The Anti-inflammatory Effect of Chitosan Oligosaccharide on Heart Failure in Mice Zhang, Yubiao Wang, Yu Liu, Yunen Gong, Tianxing Hou, Mingxiao Biomed Res Int Research Article Heart failure is currently one of the leading causes of death worldwide, and the inflammatory factors play an important role in its development. Chitosan oligosaccharide (COS), a low-molecular-weight form of chitosan, has many specific biological activities. In this study, COS effects on heart failure were studied for the first time by performing transverse arch constriction (TAC) surgery in mice, as an animal model of heart failure. Our findings revealed that COS administration (in both 40 mg/kg and 80 mg/kg doses) significantly ameliorated TCA-induced left ventricular (LV) hypertrophy as well as the increase in lung and heart weight in mice, while improving TAC-induced LV dysfunction. Both doses effectively attenuated LV cardiomyocyte hypertrophy, while decreasing heart inflammation after heart failure in mice. In conclusion, our results indicated that the supplementation of COS in normal diet might be an effective way to prevent further myocardial tissue damage in patients suffering from heart failure. Hindawi 2022-10-05 /pmc/articles/PMC9556196/ /pubmed/36246979 http://dx.doi.org/10.1155/2022/8746530 Text en Copyright © 2022 Yubiao Zhang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Yubiao
Wang, Yu
Liu, Yunen
Gong, Tianxing
Hou, Mingxiao
The Anti-inflammatory Effect of Chitosan Oligosaccharide on Heart Failure in Mice
title The Anti-inflammatory Effect of Chitosan Oligosaccharide on Heart Failure in Mice
title_full The Anti-inflammatory Effect of Chitosan Oligosaccharide on Heart Failure in Mice
title_fullStr The Anti-inflammatory Effect of Chitosan Oligosaccharide on Heart Failure in Mice
title_full_unstemmed The Anti-inflammatory Effect of Chitosan Oligosaccharide on Heart Failure in Mice
title_short The Anti-inflammatory Effect of Chitosan Oligosaccharide on Heart Failure in Mice
title_sort anti-inflammatory effect of chitosan oligosaccharide on heart failure in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556196/
https://www.ncbi.nlm.nih.gov/pubmed/36246979
http://dx.doi.org/10.1155/2022/8746530
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