Collagenous Colitis Possibly Associated with Dipeptidyl Peptidase-4 Inhibitor

A 60-year-old man with type 2 diabetes mellitus treated with a dipeptidyl peptidase-4 (DPP-4) inhibitor was referred to our hospital because of his refractory watery diarrhea. Ileocolonoscopy revealed increased capillary growth, fine granular mucosa, and longitudinal mucosal tears mainly in the left...

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Autores principales: Takedomi, Hironobu, Sakata, Yasuhisa, Tomonaga, Michito, Naruse, Naomi, Yukimoto, Takahiro, Akutagawa, Takashi, Tsuruoka, Nanae, Shimoda, Ryo, Kido, Shinichi, Esaki, Motohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556224/
https://www.ncbi.nlm.nih.gov/pubmed/35135927
http://dx.doi.org/10.2169/internalmedicine.9040-21
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author Takedomi, Hironobu
Sakata, Yasuhisa
Tomonaga, Michito
Naruse, Naomi
Yukimoto, Takahiro
Akutagawa, Takashi
Tsuruoka, Nanae
Shimoda, Ryo
Kido, Shinichi
Esaki, Motohiro
author_facet Takedomi, Hironobu
Sakata, Yasuhisa
Tomonaga, Michito
Naruse, Naomi
Yukimoto, Takahiro
Akutagawa, Takashi
Tsuruoka, Nanae
Shimoda, Ryo
Kido, Shinichi
Esaki, Motohiro
author_sort Takedomi, Hironobu
collection PubMed
description A 60-year-old man with type 2 diabetes mellitus treated with a dipeptidyl peptidase-4 (DPP-4) inhibitor was referred to our hospital because of his refractory watery diarrhea. Ileocolonoscopy revealed increased capillary growth, fine granular mucosa, and longitudinal mucosal tears mainly in the left side of the colon. A bioptic examination revealed thickened subepithelial collagen bands, thus confirming the diagnosis of collagenous colitis. Systemic steroid therapy was initiated, but his symptoms recurred when tapering the steroid. However, withdrawal of the DPP-4 inhibitor was successful even after the cessation of steroid therapy. We therefore considered his collagenous colitis to have been caused by the DPP-4 inhibitor.
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spelling pubmed-95562242022-10-27 Collagenous Colitis Possibly Associated with Dipeptidyl Peptidase-4 Inhibitor Takedomi, Hironobu Sakata, Yasuhisa Tomonaga, Michito Naruse, Naomi Yukimoto, Takahiro Akutagawa, Takashi Tsuruoka, Nanae Shimoda, Ryo Kido, Shinichi Esaki, Motohiro Intern Med Case Report A 60-year-old man with type 2 diabetes mellitus treated with a dipeptidyl peptidase-4 (DPP-4) inhibitor was referred to our hospital because of his refractory watery diarrhea. Ileocolonoscopy revealed increased capillary growth, fine granular mucosa, and longitudinal mucosal tears mainly in the left side of the colon. A bioptic examination revealed thickened subepithelial collagen bands, thus confirming the diagnosis of collagenous colitis. Systemic steroid therapy was initiated, but his symptoms recurred when tapering the steroid. However, withdrawal of the DPP-4 inhibitor was successful even after the cessation of steroid therapy. We therefore considered his collagenous colitis to have been caused by the DPP-4 inhibitor. The Japanese Society of Internal Medicine 2022-02-08 2022-09-15 /pmc/articles/PMC9556224/ /pubmed/35135927 http://dx.doi.org/10.2169/internalmedicine.9040-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Takedomi, Hironobu
Sakata, Yasuhisa
Tomonaga, Michito
Naruse, Naomi
Yukimoto, Takahiro
Akutagawa, Takashi
Tsuruoka, Nanae
Shimoda, Ryo
Kido, Shinichi
Esaki, Motohiro
Collagenous Colitis Possibly Associated with Dipeptidyl Peptidase-4 Inhibitor
title Collagenous Colitis Possibly Associated with Dipeptidyl Peptidase-4 Inhibitor
title_full Collagenous Colitis Possibly Associated with Dipeptidyl Peptidase-4 Inhibitor
title_fullStr Collagenous Colitis Possibly Associated with Dipeptidyl Peptidase-4 Inhibitor
title_full_unstemmed Collagenous Colitis Possibly Associated with Dipeptidyl Peptidase-4 Inhibitor
title_short Collagenous Colitis Possibly Associated with Dipeptidyl Peptidase-4 Inhibitor
title_sort collagenous colitis possibly associated with dipeptidyl peptidase-4 inhibitor
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556224/
https://www.ncbi.nlm.nih.gov/pubmed/35135927
http://dx.doi.org/10.2169/internalmedicine.9040-21
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