Aseptic Meningitis after Amenamevir Treatment for Herpes Zoster in the First Branch of the Trigeminal Nerve

Amenamevir has been approved for the treatment of herpes zoster (HZ); however, its therapeutic efficacy against central nervous system (CNS) infection may be insufficient due to its low spinal fluid permeability. We herein report a case of aseptic meningitis in a 91-year-old Japanese man treated wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Itoh, Kazuhiro, Mitsuke, Yasuhiko, Wakahara, Mami, Yoshioka, Tatsuya, Otsuki, Nozomi, Suzuki, Yusuke, Kiriba, Chiyo, Kuwata, Atsushi, Sakamaki, Ippei, Iwasaki, Hiromichi, Tsutani, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556230/
https://www.ncbi.nlm.nih.gov/pubmed/35228415
http://dx.doi.org/10.2169/internalmedicine.8581-21
_version_ 1784807028784365568
author Itoh, Kazuhiro
Mitsuke, Yasuhiko
Wakahara, Mami
Yoshioka, Tatsuya
Otsuki, Nozomi
Suzuki, Yusuke
Kiriba, Chiyo
Kuwata, Atsushi
Sakamaki, Ippei
Iwasaki, Hiromichi
Tsutani, Hiroshi
author_facet Itoh, Kazuhiro
Mitsuke, Yasuhiko
Wakahara, Mami
Yoshioka, Tatsuya
Otsuki, Nozomi
Suzuki, Yusuke
Kiriba, Chiyo
Kuwata, Atsushi
Sakamaki, Ippei
Iwasaki, Hiromichi
Tsutani, Hiroshi
author_sort Itoh, Kazuhiro
collection PubMed
description Amenamevir has been approved for the treatment of herpes zoster (HZ); however, its therapeutic efficacy against central nervous system (CNS) infection may be insufficient due to its low spinal fluid permeability. We herein report a case of aseptic meningitis in a 91-year-old Japanese man treated with amenamevir for HZ in the trigeminal nerve region. Several cases of CNS infection have been reported in patients receiving amenamevir treatment for HZ. Patients with CNS complications often have skin rashes near the trigeminal region. Thus, we should be alert for signs of CNS infection when administering amenamevir to patients with such rashes.
format Online
Article
Text
id pubmed-9556230
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-95562302022-10-27 Aseptic Meningitis after Amenamevir Treatment for Herpes Zoster in the First Branch of the Trigeminal Nerve Itoh, Kazuhiro Mitsuke, Yasuhiko Wakahara, Mami Yoshioka, Tatsuya Otsuki, Nozomi Suzuki, Yusuke Kiriba, Chiyo Kuwata, Atsushi Sakamaki, Ippei Iwasaki, Hiromichi Tsutani, Hiroshi Intern Med Case Report Amenamevir has been approved for the treatment of herpes zoster (HZ); however, its therapeutic efficacy against central nervous system (CNS) infection may be insufficient due to its low spinal fluid permeability. We herein report a case of aseptic meningitis in a 91-year-old Japanese man treated with amenamevir for HZ in the trigeminal nerve region. Several cases of CNS infection have been reported in patients receiving amenamevir treatment for HZ. Patients with CNS complications often have skin rashes near the trigeminal region. Thus, we should be alert for signs of CNS infection when administering amenamevir to patients with such rashes. The Japanese Society of Internal Medicine 2022-02-26 2022-09-15 /pmc/articles/PMC9556230/ /pubmed/35228415 http://dx.doi.org/10.2169/internalmedicine.8581-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Itoh, Kazuhiro
Mitsuke, Yasuhiko
Wakahara, Mami
Yoshioka, Tatsuya
Otsuki, Nozomi
Suzuki, Yusuke
Kiriba, Chiyo
Kuwata, Atsushi
Sakamaki, Ippei
Iwasaki, Hiromichi
Tsutani, Hiroshi
Aseptic Meningitis after Amenamevir Treatment for Herpes Zoster in the First Branch of the Trigeminal Nerve
title Aseptic Meningitis after Amenamevir Treatment for Herpes Zoster in the First Branch of the Trigeminal Nerve
title_full Aseptic Meningitis after Amenamevir Treatment for Herpes Zoster in the First Branch of the Trigeminal Nerve
title_fullStr Aseptic Meningitis after Amenamevir Treatment for Herpes Zoster in the First Branch of the Trigeminal Nerve
title_full_unstemmed Aseptic Meningitis after Amenamevir Treatment for Herpes Zoster in the First Branch of the Trigeminal Nerve
title_short Aseptic Meningitis after Amenamevir Treatment for Herpes Zoster in the First Branch of the Trigeminal Nerve
title_sort aseptic meningitis after amenamevir treatment for herpes zoster in the first branch of the trigeminal nerve
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556230/
https://www.ncbi.nlm.nih.gov/pubmed/35228415
http://dx.doi.org/10.2169/internalmedicine.8581-21
work_keys_str_mv AT itohkazuhiro asepticmeningitisafteramenamevirtreatmentforherpeszosterinthefirstbranchofthetrigeminalnerve
AT mitsukeyasuhiko asepticmeningitisafteramenamevirtreatmentforherpeszosterinthefirstbranchofthetrigeminalnerve
AT wakaharamami asepticmeningitisafteramenamevirtreatmentforherpeszosterinthefirstbranchofthetrigeminalnerve
AT yoshiokatatsuya asepticmeningitisafteramenamevirtreatmentforherpeszosterinthefirstbranchofthetrigeminalnerve
AT otsukinozomi asepticmeningitisafteramenamevirtreatmentforherpeszosterinthefirstbranchofthetrigeminalnerve
AT suzukiyusuke asepticmeningitisafteramenamevirtreatmentforherpeszosterinthefirstbranchofthetrigeminalnerve
AT kiribachiyo asepticmeningitisafteramenamevirtreatmentforherpeszosterinthefirstbranchofthetrigeminalnerve
AT kuwataatsushi asepticmeningitisafteramenamevirtreatmentforherpeszosterinthefirstbranchofthetrigeminalnerve
AT sakamakiippei asepticmeningitisafteramenamevirtreatmentforherpeszosterinthefirstbranchofthetrigeminalnerve
AT iwasakihiromichi asepticmeningitisafteramenamevirtreatmentforherpeszosterinthefirstbranchofthetrigeminalnerve
AT tsutanihiroshi asepticmeningitisafteramenamevirtreatmentforherpeszosterinthefirstbranchofthetrigeminalnerve

Ejemplares similares