Secondary Skin Cancer in a Case with Long-term Voriconazole after Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia

Secondary malignancies that develop after allogeneic-hematopoietic stem cell transplantation (allo-HSCT) have become serious issues. A 47-year-old man who developed acute myeloid leukemia in 2009 and subsequently underwent allo-HSCT twice: in 2009 and 2011. In 2015, voriconazole for lung aspergillus...

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Detalles Bibliográficos
Autores principales: Kawano, Noriaki, Nakamura, Shunou, Mochida, Kousuke, Yoshida, Shuro, Kuriyama, Takuro, Nakaike, Takashi, Shimokawa, Tomonori, Tochigi, Taro, Yamashita, Kiyoshi, Mashiba, Koichi, Kikuchi, Ikuo, Takarabe, Aina, Moriguchi, Sayaka, Mori, Yasuo, Takenaka, Katsuto, Shimoda, Kazuya, Ochiai, Hidenobu, Amano, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556231/
https://www.ncbi.nlm.nih.gov/pubmed/35022348
http://dx.doi.org/10.2169/internalmedicine.8618-21
Descripción
Sumario:Secondary malignancies that develop after allogeneic-hematopoietic stem cell transplantation (allo-HSCT) have become serious issues. A 47-year-old man who developed acute myeloid leukemia in 2009 and subsequently underwent allo-HSCT twice: in 2009 and 2011. In 2015, voriconazole for lung aspergillus was started. In 2018, chronic graft-versus-host disease (GVHD) and multiple actinic keratoses manifested at his head. In 2020, some lesions were diagnosed as squamous cell carcinoma, so voriconazole was withdrawn, and subsequent surgery and radiation led to remission. Long-term administration of voriconazole in addition to allo-HSCT and chronic GVHD may be closely related to secondary skin cancer.

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