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The Colon Wall Thickness Measured Using Transabdominal Ultrasonography Is Useful for Detecting Mucosal Inflammation in Ulcerative Colitis

OBJECTIVE: Transabdominal ultrasonography (TUS) is a non-invasive procedure that is reportedly useful for managing ulcerative colitis (UC) and assessing bowel wall thickness (BWT), the most common measure of mucosal inflammation. However, the exact range of BWT that reflects disease activity remains...

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Autores principales: Takahara, Masahiro, Hiraoka, Sakiko, Ohmori, Masayasu, Takeuchi, Keiko, Takei, Kensuke, Yasutomi, Eriko, Igawa, Shoko, Yamamoto, Shumpei, Yamasaki, Yasushi, Inokuchi, Toshihiro, Kinugasa, Hideaki, Harada, Keita, Ohnishi, Hideki, Okada, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556236/
https://www.ncbi.nlm.nih.gov/pubmed/35185047
http://dx.doi.org/10.2169/internalmedicine.8827-21
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author Takahara, Masahiro
Hiraoka, Sakiko
Ohmori, Masayasu
Takeuchi, Keiko
Takei, Kensuke
Yasutomi, Eriko
Igawa, Shoko
Yamamoto, Shumpei
Yamasaki, Yasushi
Inokuchi, Toshihiro
Kinugasa, Hideaki
Harada, Keita
Ohnishi, Hideki
Okada, Hiroyuki
author_facet Takahara, Masahiro
Hiraoka, Sakiko
Ohmori, Masayasu
Takeuchi, Keiko
Takei, Kensuke
Yasutomi, Eriko
Igawa, Shoko
Yamamoto, Shumpei
Yamasaki, Yasushi
Inokuchi, Toshihiro
Kinugasa, Hideaki
Harada, Keita
Ohnishi, Hideki
Okada, Hiroyuki
author_sort Takahara, Masahiro
collection PubMed
description OBJECTIVE: Transabdominal ultrasonography (TUS) is a non-invasive procedure that is reportedly useful for managing ulcerative colitis (UC) and assessing bowel wall thickness (BWT), the most common measure of mucosal inflammation. However, the exact range of BWT that reflects disease activity remains undetermined. The present study clarified the BWT due to disease activity by comparing the use of TUS in each segment of the colon versus using colonoscopy (CS) and determined the usefulness of TUS in patients with UC. METHODS: We divided the colon into five segments and measured the BWT using TUS. The results were then compared to the Mayo endoscopic subscore (MES) classification to determine the accuracy of BWT measurement. PATIENTS: Eighty patients with UC who underwent TUS within 14 days of CS were retrospectively registered. RESULTS: We evaluated a total of 268 images depicting each segment among 80 patients with UC. The BWT was positively correlated with endoscopic activity (0.69, p<0.0001). In each segment, the relationship between a BWT>2 mm and an MES>0 had the highest sensitivity, specificity, and accuracy (0.85-1.00, 0.67-0.92, and 0.81-0.97, respectively). CONCLUSION: This study concluded that TUS was a useful method of detecting an MES>0, which indicates the presence of inflammation and its location among UC patients. MES>0 was found to be highly accurate when a BWT>2 mm was considered positive. This non-invasive method may help control disease activity in patients with UC.
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spelling pubmed-95562362022-10-27 The Colon Wall Thickness Measured Using Transabdominal Ultrasonography Is Useful for Detecting Mucosal Inflammation in Ulcerative Colitis Takahara, Masahiro Hiraoka, Sakiko Ohmori, Masayasu Takeuchi, Keiko Takei, Kensuke Yasutomi, Eriko Igawa, Shoko Yamamoto, Shumpei Yamasaki, Yasushi Inokuchi, Toshihiro Kinugasa, Hideaki Harada, Keita Ohnishi, Hideki Okada, Hiroyuki Intern Med Original Article OBJECTIVE: Transabdominal ultrasonography (TUS) is a non-invasive procedure that is reportedly useful for managing ulcerative colitis (UC) and assessing bowel wall thickness (BWT), the most common measure of mucosal inflammation. However, the exact range of BWT that reflects disease activity remains undetermined. The present study clarified the BWT due to disease activity by comparing the use of TUS in each segment of the colon versus using colonoscopy (CS) and determined the usefulness of TUS in patients with UC. METHODS: We divided the colon into five segments and measured the BWT using TUS. The results were then compared to the Mayo endoscopic subscore (MES) classification to determine the accuracy of BWT measurement. PATIENTS: Eighty patients with UC who underwent TUS within 14 days of CS were retrospectively registered. RESULTS: We evaluated a total of 268 images depicting each segment among 80 patients with UC. The BWT was positively correlated with endoscopic activity (0.69, p<0.0001). In each segment, the relationship between a BWT>2 mm and an MES>0 had the highest sensitivity, specificity, and accuracy (0.85-1.00, 0.67-0.92, and 0.81-0.97, respectively). CONCLUSION: This study concluded that TUS was a useful method of detecting an MES>0, which indicates the presence of inflammation and its location among UC patients. MES>0 was found to be highly accurate when a BWT>2 mm was considered positive. This non-invasive method may help control disease activity in patients with UC. The Japanese Society of Internal Medicine 2022-02-19 2022-09-15 /pmc/articles/PMC9556236/ /pubmed/35185047 http://dx.doi.org/10.2169/internalmedicine.8827-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Takahara, Masahiro
Hiraoka, Sakiko
Ohmori, Masayasu
Takeuchi, Keiko
Takei, Kensuke
Yasutomi, Eriko
Igawa, Shoko
Yamamoto, Shumpei
Yamasaki, Yasushi
Inokuchi, Toshihiro
Kinugasa, Hideaki
Harada, Keita
Ohnishi, Hideki
Okada, Hiroyuki
The Colon Wall Thickness Measured Using Transabdominal Ultrasonography Is Useful for Detecting Mucosal Inflammation in Ulcerative Colitis
title The Colon Wall Thickness Measured Using Transabdominal Ultrasonography Is Useful for Detecting Mucosal Inflammation in Ulcerative Colitis
title_full The Colon Wall Thickness Measured Using Transabdominal Ultrasonography Is Useful for Detecting Mucosal Inflammation in Ulcerative Colitis
title_fullStr The Colon Wall Thickness Measured Using Transabdominal Ultrasonography Is Useful for Detecting Mucosal Inflammation in Ulcerative Colitis
title_full_unstemmed The Colon Wall Thickness Measured Using Transabdominal Ultrasonography Is Useful for Detecting Mucosal Inflammation in Ulcerative Colitis
title_short The Colon Wall Thickness Measured Using Transabdominal Ultrasonography Is Useful for Detecting Mucosal Inflammation in Ulcerative Colitis
title_sort colon wall thickness measured using transabdominal ultrasonography is useful for detecting mucosal inflammation in ulcerative colitis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556236/
https://www.ncbi.nlm.nih.gov/pubmed/35185047
http://dx.doi.org/10.2169/internalmedicine.8827-21
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