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Crenigacestat (LY3039478) inhibits osteogenic differentiation of human valve interstitial cells from patients with aortic valve calcification in vitro

Calcific aortic valve disease (CAVD) is one of the dangerous forms of vascular calcification. CAVD leads to calcification of the aortic valve and disturbance of blood flow. Despite high mortality, there is no targeted therapy against CAVD or vascular calcification. Osteogenic differentiation of valv...

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Detalles Bibliográficos
Autores principales:	Lobov, Arseniy A., Boyarskaya, Nadezhda V., Kachanova, Olga S., Gromova, Ekaterina S., Shishkova, Anastassia A., Zainullina, Bozhana R., Pishchugin, Alexander S., Filippov, Alexey A., Uspensky, Vladimir E., Malashicheva, Anna B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cardiovascular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556293/ https://www.ncbi.nlm.nih.gov/pubmed/36247471 http://dx.doi.org/10.3389/fcvm.2022.969096

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