Cargando…

Antipsychotic Medication and Risk of Incident Seizure in People with Autism Spectrum Disorder: Analyses with Cohort and Within Individual Study Designs

There are many case reports of seizures apparently associated with the prescription of antipsychotics. This study aimed to examine whether there is an association between the prescription of antipsychotics and incident seizures in individuals with autism spectrum disorder using retrospective data ba...

Descripción completa

Detalles Bibliográficos
Autores principales: Alfageh, Basmah H., Besag, Frank M. C., Gao, Le, Ma, Tian-Tian, Man, Kenneth K. C., Wong, Ian C. K., Brauer, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556371/
https://www.ncbi.nlm.nih.gov/pubmed/34751867
http://dx.doi.org/10.1007/s10803-021-05208-0
_version_ 1784807063424073728
author Alfageh, Basmah H.
Besag, Frank M. C.
Gao, Le
Ma, Tian-Tian
Man, Kenneth K. C.
Wong, Ian C. K.
Brauer, Ruth
author_facet Alfageh, Basmah H.
Besag, Frank M. C.
Gao, Le
Ma, Tian-Tian
Man, Kenneth K. C.
Wong, Ian C. K.
Brauer, Ruth
author_sort Alfageh, Basmah H.
collection PubMed
description There are many case reports of seizures apparently associated with the prescription of antipsychotics. This study aimed to examine whether there is an association between the prescription of antipsychotics and incident seizures in individuals with autism spectrum disorder using retrospective data based on patients’ chart review. A cohort study was conducted to compare the rate of incident seizure between 3923 users of antipsychotics with 10,086 users of other psychotropics. This was followed by a self-controlled case series (SCCS) analysis of 149 patients to eliminate the effect of time-invariant confounders. The results showed no evidence of increased risk of seizure after exposure to antipsychotic agents (Hazard Ratio 1.28, 95% CI 0.74–2.19) compared to other psychotropics. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10803-021-05208-0.
format Online
Article
Text
id pubmed-9556371
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-95563712022-10-14 Antipsychotic Medication and Risk of Incident Seizure in People with Autism Spectrum Disorder: Analyses with Cohort and Within Individual Study Designs Alfageh, Basmah H. Besag, Frank M. C. Gao, Le Ma, Tian-Tian Man, Kenneth K. C. Wong, Ian C. K. Brauer, Ruth J Autism Dev Disord Original Paper There are many case reports of seizures apparently associated with the prescription of antipsychotics. This study aimed to examine whether there is an association between the prescription of antipsychotics and incident seizures in individuals with autism spectrum disorder using retrospective data based on patients’ chart review. A cohort study was conducted to compare the rate of incident seizure between 3923 users of antipsychotics with 10,086 users of other psychotropics. This was followed by a self-controlled case series (SCCS) analysis of 149 patients to eliminate the effect of time-invariant confounders. The results showed no evidence of increased risk of seizure after exposure to antipsychotic agents (Hazard Ratio 1.28, 95% CI 0.74–2.19) compared to other psychotropics. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10803-021-05208-0. Springer US 2021-11-09 2022 /pmc/articles/PMC9556371/ /pubmed/34751867 http://dx.doi.org/10.1007/s10803-021-05208-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Alfageh, Basmah H.
Besag, Frank M. C.
Gao, Le
Ma, Tian-Tian
Man, Kenneth K. C.
Wong, Ian C. K.
Brauer, Ruth
Antipsychotic Medication and Risk of Incident Seizure in People with Autism Spectrum Disorder: Analyses with Cohort and Within Individual Study Designs
title Antipsychotic Medication and Risk of Incident Seizure in People with Autism Spectrum Disorder: Analyses with Cohort and Within Individual Study Designs
title_full Antipsychotic Medication and Risk of Incident Seizure in People with Autism Spectrum Disorder: Analyses with Cohort and Within Individual Study Designs
title_fullStr Antipsychotic Medication and Risk of Incident Seizure in People with Autism Spectrum Disorder: Analyses with Cohort and Within Individual Study Designs
title_full_unstemmed Antipsychotic Medication and Risk of Incident Seizure in People with Autism Spectrum Disorder: Analyses with Cohort and Within Individual Study Designs
title_short Antipsychotic Medication and Risk of Incident Seizure in People with Autism Spectrum Disorder: Analyses with Cohort and Within Individual Study Designs
title_sort antipsychotic medication and risk of incident seizure in people with autism spectrum disorder: analyses with cohort and within individual study designs
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556371/
https://www.ncbi.nlm.nih.gov/pubmed/34751867
http://dx.doi.org/10.1007/s10803-021-05208-0
work_keys_str_mv AT alfagehbasmahh antipsychoticmedicationandriskofincidentseizureinpeoplewithautismspectrumdisorderanalyseswithcohortandwithinindividualstudydesigns
AT besagfrankmc antipsychoticmedicationandriskofincidentseizureinpeoplewithautismspectrumdisorderanalyseswithcohortandwithinindividualstudydesigns
AT gaole antipsychoticmedicationandriskofincidentseizureinpeoplewithautismspectrumdisorderanalyseswithcohortandwithinindividualstudydesigns
AT matiantian antipsychoticmedicationandriskofincidentseizureinpeoplewithautismspectrumdisorderanalyseswithcohortandwithinindividualstudydesigns
AT mankennethkc antipsychoticmedicationandriskofincidentseizureinpeoplewithautismspectrumdisorderanalyseswithcohortandwithinindividualstudydesigns
AT wongianck antipsychoticmedicationandriskofincidentseizureinpeoplewithautismspectrumdisorderanalyseswithcohortandwithinindividualstudydesigns
AT brauerruth antipsychoticmedicationandriskofincidentseizureinpeoplewithautismspectrumdisorderanalyseswithcohortandwithinindividualstudydesigns