Molecular analysis of OXA-48-producing Escherichia coli in Switzerland from 2019 to 2020

OXA-48-type ß-lactamases are the most prevalent carbapenemase-type in Enterobacterales in Switzerland, predominantly found in Escherichia coli and Klebsiella pneumoniae. Bacteria-producing OXA-48-type enzymes are endemic in some parts of the world, including Europe and North Africa, and are a freque...

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Detalles Bibliográficos
Autores principales: Findlay, Jacqueline, Perreten, Vincent, Poirel, Laurent, Nordmann, Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556411/
https://www.ncbi.nlm.nih.gov/pubmed/36103096
http://dx.doi.org/10.1007/s10096-022-04493-6
Descripción
Sumario:OXA-48-type ß-lactamases are the most prevalent carbapenemase-type in Enterobacterales in Switzerland, predominantly found in Escherichia coli and Klebsiella pneumoniae. Bacteria-producing OXA-48-type enzymes are endemic in some parts of the world, including Europe and North Africa, and are a frequent cause of nosocomial infections. Despite the emergence of numerous OXA-48-type variants, the original variant, OXA-48, remains the most prevalent in E. coli. This study describes the epidemiology of OXA-48-producing E. coli isolates submitted to the Swiss National Reference Center for Emerging Antibiotic Resistance (NARA) between January 2019 and December 2020. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10096-022-04493-6.

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