Structural insight into the bulge-containing KRAS oncogene promoter G-quadruplex bound to berberine and coptisine

KRAS is one of the most highly mutated oncoproteins, which is overexpressed in various human cancers and implicated in poor survival. The G-quadruplex formed in KRAS oncogene promoter (KRAS-G4) is a transcriptional modulator and amenable to small molecule targeting. However, no available KRAS-G4-lig...

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Detalles Bibliográficos
Autores principales: Wang, Kai-Bo, Liu, Yushuang, Li, Jinzhu, Xiao, Chengmei, Wang, Yingying, Gu, Wei, Li, Yipu, Xia, Yuan-Zheng, Yan, Tingdong, Yang, Ming-Hua, Kong, Ling-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556435/
https://www.ncbi.nlm.nih.gov/pubmed/36224201
http://dx.doi.org/10.1038/s41467-022-33761-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556435/
https://www.ncbi.nlm.nih.gov/pubmed/36224201
http://dx.doi.org/10.1038/s41467-022-33761-4

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