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Structural insight into the bulge-containing KRAS oncogene promoter G-quadruplex bound to berberine and coptisine
KRAS is one of the most highly mutated oncoproteins, which is overexpressed in various human cancers and implicated in poor survival. The G-quadruplex formed in KRAS oncogene promoter (KRAS-G4) is a transcriptional modulator and amenable to small molecule targeting. However, no available KRAS-G4-lig...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556435/ https://www.ncbi.nlm.nih.gov/pubmed/36224201 http://dx.doi.org/10.1038/s41467-022-33761-4 |