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The coilin N-terminus mediates multivalent interactions between coilin and Nopp140 to form and maintain Cajal bodies

Cajal bodies (CBs) are ubiquitous nuclear membraneless organelles (MLOs) that concentrate and promote efficient biogenesis of snRNA-protein complexes involved in splicing (snRNPs). Depletion of the CB scaffolding protein coilin disperses snRNPs, making CBs a model system for studying the structure a...

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Detalles Bibliográficos
Autores principales:	Courchaine, Edward, Gelles-Watnick, Sara, Machyna, Martin, Straube, Korinna, Sauyet, Sarah, Enright, Jade, Neugebauer, Karla M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556525/ https://www.ncbi.nlm.nih.gov/pubmed/36224177 http://dx.doi.org/10.1038/s41467-022-33434-2

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