Targeting EGFR-dependent tumors by disrupting an ARF6-mediated sorting system

Aberrant activation of EGFR due to overexpression or mutation is associated with poor prognosis in many types of tumors. Here we show that blocking the sorting system that directs EGFR to plasma membrane is a potent strategy to treat EGFR-dependent tumors. We find that EGFR palmitoylation by DHHC13...

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Detalles Bibliográficos
Autores principales: Guo, Huiling, Wang, Juan, Ren, Su, Zheng, Lang-Fan, Zhuang, Yi-Xuan, Li, Dong-Lin, Sun, Hui-Hui, Liu, Li-Ying, Xie, Changchuan, Wu, Ya-Ying, Wang, Hong-Rui, Deng, Xianming, Li, Peng, Zhao, Tong-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556547/
https://www.ncbi.nlm.nih.gov/pubmed/36224181
http://dx.doi.org/10.1038/s41467-022-33788-7

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