Generation and characterization of human U-2 OS cell lines with the CRISPR/Cas9-edited protoporphyrinogen oxidase IX gene

In humans, disruptions in the heme biosynthetic pathway are associated with various types of porphyrias, including variegate porphyria that results from the decreased activity of protoporphyrinogen oxidase IX (PPO; E.C.1.3.3.4), the enzyme catalyzing the penultimate step of the heme biosynthesis. He...

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Detalles Bibliográficos
Autores principales: Novakova, Zora, Milosevic, Mirko, Kutil, Zsofia, Ondrakova, Marketa, Havlinova, Barbora, Kasparek, Petr, Sandoval-Acuña, Cristian, Korandova, Zuzana, Truksa, Jaroslav, Vrbacky, Marek, Rohlena, Jakub, Barinka, Cyril
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556554/
https://www.ncbi.nlm.nih.gov/pubmed/36224252
http://dx.doi.org/10.1038/s41598-022-21147-x

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