Cargando…

Metformin alleviates neurocognitive impairment in aging via activation of AMPK/BDNF/PI3K pathway

Slowing down age-related neurocognitive impairment has been a challenge. We evaluated the therapeutic effects of metformin in d-galactose-induced aging. Additionally, we studied the potential molecular mechanisms that could be responsible for metformin's anti-aging effects. Thirty male rats wer...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ameen, Omnia, Samaka, Rehab M., Abo-Elsoud, Reda A. A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556637/ https://www.ncbi.nlm.nih.gov/pubmed/36224264 http://dx.doi.org/10.1038/s41598-022-20945-7

Ejemplares similares

Autophagy and mTOR Pathways Mediate the Potential Renoprotective Effects of Vitamin D on Diabetic Nephropathy
por: Khodir, Suzan A., et al.
Publicado: (2020)

Metformin alleviates the calcification of aortic valve interstitial cells through activating the PI3K/AKT pathway in an AMPK dependent way
por: En, Qiao, et al.
Publicado: (2021)

Countering adipose tissue dysfunction could underlie the superiority of telmisartan in the treatment of obesity-related hypertension
por: Naguib, Yahya M., et al.
Publicado: (2021)

Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway
por: Yang, Yangliang, et al.
Publicado: (2021)

Metformin Modulates High Glucose-Incubated Human Umbilical Vein Endothelial Cells Proliferation and Apoptosis Through AMPK/CREB/BDNF Pathway
por: Han, Xiqiong, et al.
Publicado: (2018)

AMPK exerts dual regulatory effects on the PI3K pathway
por: Tao, Rong, et al.
Publicado: (2010)

Acute Administration of Metformin Protects Against Neuronal Apoptosis Induced by Cerebral Ischemia-Reperfusion Injury via Regulation of the AMPK/CREB/BDNF Pathway
por: Liu, Ke, et al.
Publicado: (2022)

Ligustrazine ameliorates lipopolysaccharide-induced neurocognitive impairment by activating autophagy via the PI3K/AKT/mTOR pathway
por: Li, Guangming, et al.
Publicado: (2020)

Corrigendum: Acute Administration of Metformin Protects Against Neuronal Apoptosis Induced by Cerebral Ischemia-Reperfusion Injury via Regulation of the AMPK/CREB/BDNF Pathway
por: Liu, Ke, et al.
Publicado: (2022)

PI3K and MAPK pathways mediate the BDNF/TrkB-increased metastasis in neuroblastoma
por: Hua, Zhongyan, et al.
Publicado: (2016)

7,8-Dihydroxycoumarin Alleviates Synaptic Loss by Activated PI3K-Akt-CREB-BDNF Signaling in Alzheimer’s Disease Model Mice
por: Yan, Li, et al.
Publicado: (2022)

AMPK alleviates high uric acid-induced Na(+)-K(+)-ATPase signaling impairment and cell injury in renal tubules
por: Xiao, Jing, et al.
Publicado: (2019)

Metformin activated AMPK signaling contributes to the alleviation of LPS-induced inflammatory responses in bovine mammary epithelial cells
por: Xu, Tianle, et al.
Publicado: (2021)

Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation
por: Groenendijk, Floris H, et al.
Publicado: (2015)

Metformin Alleviates Epirubicin-Induced Endothelial Impairment by Restoring Mitochondrial Homeostasis
por: Sun, Qi, et al.
Publicado: (2022)

Metabolic regulation by the intestinal metformin-AMPK axis
por: Zhang, Song-Yang, et al.
Publicado: (2022)

Metformin induces apoptosis and inhibits migration by activating the AMPK/p53 axis and suppressing PI3K/AKT signaling in human cervical cancer cells
por: Chen, Ya-Hui, et al.
Publicado: (2021)

Protective role of vitamin D3 in a rat model of hyperthyroid-induced cardiomyopathy
por: Salem, Heba Rady, et al.
Publicado: (2023)

Huge pelvic parachordoma: fine needle aspiration cytology and histological differential diagnosis
por: Samaka, Rehab M., et al.
Publicado: (2012)

Metformin enhances the chemosensitivity of hepatocarcinoma cells to cisplatin through AMPK pathway
por: Dong, Hao, et al.
Publicado: (2017)

BDNF, GDNF, NGF and Klotho levels and neurocognitive functions in acute term of schizophrenia
por: Turkmen, Betul Aslan, et al.
Publicado: (2021)

Metformin attenuates osteoclast-mediated abnormal subchondral bone remodeling and alleviates osteoarthritis via AMPK/NF-κB/ERK signaling pathway
por: Guo, Haohui, et al.
Publicado: (2021)

Histamine 2/3 receptor agonists alleviate perioperative neurocognitive disorders by inhibiting microglia activation through the PI3K/AKT/FoxO1 pathway in aged rats
por: Chen, Yi-Nan, et al.
Publicado: (2020)

Metformin alleviates lead-induced mitochondrial fragmentation via AMPK/Nrf2 activation in SH-SY5Y cells
por: Yang, Luoyao, et al.
Publicado: (2020)

Metformin alleviates β-glycerophosphate-induced calcification of vascular smooth muscle cells via AMPK/mTOR-activated autophagy
por: Qiu, Xiaobo, et al.
Publicado: (2021)

Metformin alleviates oxidative stress‐induced senescence of human lens epithelial cells via AMPK activation and autophagic flux restoration
por: Chen, Mengmeng, et al.
Publicado: (2021)

Moringa oleifera alcoholic extract protected stomach from bisphenol A–induced gastric ulcer in rats via its anti-oxidant and anti-inflammatory activities
por: Abo-Elsoud, Reda Abo Elfath Ahmed, et al.
Publicado: (2022)

Metformin alleviates bevacizumab-induced vascular endothelial injury by up-regulating GDF15 and activating the PI3K/AKT/FOXO/PPARγ signaling pathway
por: Chen, Liqiang, et al.
Publicado: (2021)

Quercetin ameliorates chicken quality by activating the PI3K/PKB/AMPK signaling pathway in broilers
por: Wang, Mi, et al.
Publicado: (2022)

The Metformin Mechanism on Gluconeogenesis and AMPK Activation: The Metabolite Perspective
por: Agius, Loranne, et al.
Publicado: (2020)

Demystifying the Relationship Between Metformin, AMPK, and Doxorubicin Cardiotoxicity
por: Singh, Manrose, et al.
Publicado: (2022)

Differential crosstalk between the AMPK and PI3K/Akt pathways in breast cancer cells of differing genotypes: Leptin inhibits the effectiveness of AMPK activation
por: EL-MASRY, OMAR S., et al.
Publicado: (2015)

Enriched Environment Prevents Hypobaric Hypoxia Induced Memory Impairment and Neurodegeneration: Role of BDNF/PI3K/GSK3β Pathway Coupled with CREB Activation
por: Jain, Vishal, et al.
Publicado: (2013)

Serum BDNF and GDNF in Chinese male patients with deficit schizophrenia and their relationships with neurocognitive dysfunction
por: Tang, Xiaowei, et al.
Publicado: (2019)

Antihyperglycemic mechanism of metformin occurs via the AMPK/LXRα/POMC pathway
por: Cho, Kumsun, et al.
Publicado: (2015)

Low-dose metformin targets the lysosomal AMPK pathway through PEN2
por: Ma, Teng, et al.
Publicado: (2022)

Molecular and neural roles of sodium-glucose cotransporter 2 inhibitors in alleviating neurocognitive impairment in diabetic mice
por: Piątkowska-Chmiel, Iwona, et al.
Publicado: (2023)

Role of Janus kinase 1 and signal transducer and activator of transcription 3 in vitiligo
por: Samaka, Rehab M, et al.
Publicado: (2019)

Does the Autophagy Related Gene 7 (ATG7) Have a Role in Non-Melanoma Skin Cancer?
por: Samaka, Rehab M, et al.
Publicado: (2020)

Antidiabetic Effect of Artemether in Db/Db Mice Involves Regulation of AMPK and PI3K/Akt Pathways
por: Bai, Xiaolin, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_18v1j0a83ffjqat3bpguov4na2