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Clinical applications of circulating tumor-derived DNA in the management of gastrointestinal cancers – current evidence and future directions
Advances in Next Generation Sequencing (NGS) technologies have enabled the accurate detection and quantification of circulating tumor-derived (ct)DNA in most gastrointestinal (GI) cancers. The prognostic and predictive utility of ctDNA in patiets with different stages of colorectal (CRC), gastro-eso...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556664/ https://www.ncbi.nlm.nih.gov/pubmed/36248993 http://dx.doi.org/10.3389/fonc.2022.970242 |
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author | Lam, Rachel C. T. Johnson, David Lam, Gigi Li, Michelle L. Y. Wong, Joyce W. L. Lam, W. K. Jacky Chan, K. C. Allen Ma, Brigette |
author_facet | Lam, Rachel C. T. Johnson, David Lam, Gigi Li, Michelle L. Y. Wong, Joyce W. L. Lam, W. K. Jacky Chan, K. C. Allen Ma, Brigette |
author_sort | Lam, Rachel C. T. |
collection | PubMed |
description | Advances in Next Generation Sequencing (NGS) technologies have enabled the accurate detection and quantification of circulating tumor-derived (ct)DNA in most gastrointestinal (GI) cancers. The prognostic and predictive utility of ctDNA in patiets with different stages of colorectal (CRC), gastro-esophageal (GEC) and pancreaticobiliary cancers (PBC) are currently under active investigation. The most mature clinical data to date are derived from studies in the prognostic utility of personalized ctDNA-based NGS assays in the detection of minimal residual disease (MRD) and early recurrence after surgery in CRC and other GI cancers. These findings are being validated in several prospective studies which are designed to test if ctDNA could outperform conventional approaches in guiding adjuvant chemotherapy, and in post-operative surveillance in some GI cancers. Several adaptive studies using ctDNA as a screening platform are also being used to identify patients with actionable genomic alterations for clinical trials of targeted therapies. In the palliative setting, ctDNA monitoring during treatment has shown promise in the detection and tracking of clonal variants associated with acquired resistance to targeted therapies and immune-checkpoint inhibitors (ICI). Moreover, ctDNA may help to guide the therapeutic re-challenge of targeted therapies in patients who have prior exposure to such treatment. This review will examine the most updated research findings on ctDNA as a biomarker in CRC, GEC and PBCs. It aims to provide insights into how the unique strengths of this biomarker could be optimally leveraged in improving the management of these GI cancers. |
format | Online Article Text |
id | pubmed-9556664 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95566642022-10-14 Clinical applications of circulating tumor-derived DNA in the management of gastrointestinal cancers – current evidence and future directions Lam, Rachel C. T. Johnson, David Lam, Gigi Li, Michelle L. Y. Wong, Joyce W. L. Lam, W. K. Jacky Chan, K. C. Allen Ma, Brigette Front Oncol Oncology Advances in Next Generation Sequencing (NGS) technologies have enabled the accurate detection and quantification of circulating tumor-derived (ct)DNA in most gastrointestinal (GI) cancers. The prognostic and predictive utility of ctDNA in patiets with different stages of colorectal (CRC), gastro-esophageal (GEC) and pancreaticobiliary cancers (PBC) are currently under active investigation. The most mature clinical data to date are derived from studies in the prognostic utility of personalized ctDNA-based NGS assays in the detection of minimal residual disease (MRD) and early recurrence after surgery in CRC and other GI cancers. These findings are being validated in several prospective studies which are designed to test if ctDNA could outperform conventional approaches in guiding adjuvant chemotherapy, and in post-operative surveillance in some GI cancers. Several adaptive studies using ctDNA as a screening platform are also being used to identify patients with actionable genomic alterations for clinical trials of targeted therapies. In the palliative setting, ctDNA monitoring during treatment has shown promise in the detection and tracking of clonal variants associated with acquired resistance to targeted therapies and immune-checkpoint inhibitors (ICI). Moreover, ctDNA may help to guide the therapeutic re-challenge of targeted therapies in patients who have prior exposure to such treatment. This review will examine the most updated research findings on ctDNA as a biomarker in CRC, GEC and PBCs. It aims to provide insights into how the unique strengths of this biomarker could be optimally leveraged in improving the management of these GI cancers. Frontiers Media S.A. 2022-09-29 /pmc/articles/PMC9556664/ /pubmed/36248993 http://dx.doi.org/10.3389/fonc.2022.970242 Text en Copyright © 2022 Lam, Johnson, Lam, Li, Wong, Lam, Chan and Ma https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Lam, Rachel C. T. Johnson, David Lam, Gigi Li, Michelle L. Y. Wong, Joyce W. L. Lam, W. K. Jacky Chan, K. C. Allen Ma, Brigette Clinical applications of circulating tumor-derived DNA in the management of gastrointestinal cancers – current evidence and future directions |
title | Clinical applications of circulating tumor-derived DNA in the management of gastrointestinal cancers – current evidence and future directions |
title_full | Clinical applications of circulating tumor-derived DNA in the management of gastrointestinal cancers – current evidence and future directions |
title_fullStr | Clinical applications of circulating tumor-derived DNA in the management of gastrointestinal cancers – current evidence and future directions |
title_full_unstemmed | Clinical applications of circulating tumor-derived DNA in the management of gastrointestinal cancers – current evidence and future directions |
title_short | Clinical applications of circulating tumor-derived DNA in the management of gastrointestinal cancers – current evidence and future directions |
title_sort | clinical applications of circulating tumor-derived dna in the management of gastrointestinal cancers – current evidence and future directions |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556664/ https://www.ncbi.nlm.nih.gov/pubmed/36248993 http://dx.doi.org/10.3389/fonc.2022.970242 |
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