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Prognostic significance of lncRNA AP004608.1 in prostate cancer
This study aimed to screen and determine the value of AP004608.1 expression as a biomarker for Prostate cancer (PCa) survival. We investigated the expression and prognosis of AP004608.1 through bioinformatics analysis. Low AP004608.1 expression predicted favorable Overall survival (OS) and Progressi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556701/ https://www.ncbi.nlm.nih.gov/pubmed/36249054 http://dx.doi.org/10.3389/fonc.2022.1017635 |
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author | Li, Wei Zhou, Runze Sun, Bo Jin, Xin Chen, Yuan Xu, Xuefen |
author_facet | Li, Wei Zhou, Runze Sun, Bo Jin, Xin Chen, Yuan Xu, Xuefen |
author_sort | Li, Wei |
collection | PubMed |
description | This study aimed to screen and determine the value of AP004608.1 expression as a biomarker for Prostate cancer (PCa) survival. We investigated the expression and prognosis of AP004608.1 through bioinformatics analysis. Low AP004608.1 expression predicted favorable Overall survival (OS) and Progression-free survival (PFS) in PCa patients, according to the Cancer Genome Atlas (TCGA) database. Cox regression demonstrated that low AP004608.1 expression were in-dependent biomarkers for OS. Moreover, Gene Expression Omnibus (GEO) database was utilized to verify the prognostic role of AP004608.1 in PCa, and the similar results were reached. A meta-analysis revealed that low AP004608.1 expression was closely relevant to better OS. AP004608.1 could constitute a promising prognostic biomarker, and probably plays an important role in PCa. |
format | Online Article Text |
id | pubmed-9556701 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95567012022-10-14 Prognostic significance of lncRNA AP004608.1 in prostate cancer Li, Wei Zhou, Runze Sun, Bo Jin, Xin Chen, Yuan Xu, Xuefen Front Oncol Oncology This study aimed to screen and determine the value of AP004608.1 expression as a biomarker for Prostate cancer (PCa) survival. We investigated the expression and prognosis of AP004608.1 through bioinformatics analysis. Low AP004608.1 expression predicted favorable Overall survival (OS) and Progression-free survival (PFS) in PCa patients, according to the Cancer Genome Atlas (TCGA) database. Cox regression demonstrated that low AP004608.1 expression were in-dependent biomarkers for OS. Moreover, Gene Expression Omnibus (GEO) database was utilized to verify the prognostic role of AP004608.1 in PCa, and the similar results were reached. A meta-analysis revealed that low AP004608.1 expression was closely relevant to better OS. AP004608.1 could constitute a promising prognostic biomarker, and probably plays an important role in PCa. Frontiers Media S.A. 2022-09-29 /pmc/articles/PMC9556701/ /pubmed/36249054 http://dx.doi.org/10.3389/fonc.2022.1017635 Text en Copyright © 2022 Li, Zhou, Sun, Jin, Chen and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Li, Wei Zhou, Runze Sun, Bo Jin, Xin Chen, Yuan Xu, Xuefen Prognostic significance of lncRNA AP004608.1 in prostate cancer |
title | Prognostic significance of lncRNA AP004608.1 in prostate cancer |
title_full | Prognostic significance of lncRNA AP004608.1 in prostate cancer |
title_fullStr | Prognostic significance of lncRNA AP004608.1 in prostate cancer |
title_full_unstemmed | Prognostic significance of lncRNA AP004608.1 in prostate cancer |
title_short | Prognostic significance of lncRNA AP004608.1 in prostate cancer |
title_sort | prognostic significance of lncrna ap004608.1 in prostate cancer |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556701/ https://www.ncbi.nlm.nih.gov/pubmed/36249054 http://dx.doi.org/10.3389/fonc.2022.1017635 |
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