Mesenchymal stem cells exosomal let-7a-5p improve autophagic flux and alleviate liver injury in acute-on-chronic liver failure by promoting nuclear expression of TFEB

Acute-on-chronic liver failure is a distinct clinical syndrome characterized by a dysregulated immune response and extensive hepatocyte death without satisfactory therapies. As a cytoplasmic degradative and quality-control process, autophagy was implicated in maintaining intracellular homeostasis, a...

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Detalles Bibliográficos
Autores principales: Lin, Dengna, Chen, Hao, Xiong, Jing, Zhang, Jing, Hu, Zhaoxia, Gao, Juan, Gao, Bin, Zhang, Shaoquan, Chen, Junfeng, Cao, Huijuan, Li, Zhihui, Lin, Bingliang, Gao, Zhiliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556718/
https://www.ncbi.nlm.nih.gov/pubmed/36224178
http://dx.doi.org/10.1038/s41419-022-05303-9

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