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Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variants
BACKGROUND: COVID-19 has caused a global pandemic and the death toll is increasing. With the coronavirus continuously mutating, Omicron has replaced Delta as the most widely reported variant in the world. Studies have shown that the plasma of some vaccinated people does not neutralize the Omicron va...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556728/ https://www.ncbi.nlm.nih.gov/pubmed/36248883 http://dx.doi.org/10.3389/fimmu.2022.975533 |
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author | Xie, Yudi Liu, Lei Wang, Jue Zheng, Yaqiong Luo, Chen Ni, Wenxu He, Zhihang Zhao, Xin Liu, Yan He, Yingyu Zheng, Shangen Li, Ling Liu, Zhong |
author_facet | Xie, Yudi Liu, Lei Wang, Jue Zheng, Yaqiong Luo, Chen Ni, Wenxu He, Zhihang Zhao, Xin Liu, Yan He, Yingyu Zheng, Shangen Li, Ling Liu, Zhong |
author_sort | Xie, Yudi |
collection | PubMed |
description | BACKGROUND: COVID-19 has caused a global pandemic and the death toll is increasing. With the coronavirus continuously mutating, Omicron has replaced Delta as the most widely reported variant in the world. Studies have shown that the plasma of some vaccinated people does not neutralize the Omicron variant. However, further studies are needed to determine whether plasma neutralizes Omicron after one- or two-dose vaccine in patients who have recovered from infection with the original strain. METHODS: The pseudovirus neutralization assays were performed on 64 plasma samples of convalescent COVID-19 patients, which were divided into pre-vaccination group, one-dose vaccinated group and two-dose vaccinated group. RESULTS: In the three groups, there were significant reductions of sera neutralizing activity from WT to Delta variant (B.1.617.2), and from WT to Omicron variant (B.1.1.529) (ps<0.001), but the difference between Delta and Omicron variants were not significant (p>0.05). The average neutralization of the Omicron variant showed a significant difference between pre-vaccination and two-dose vaccinated convalescent individuals (p<0.01). CONCLUSIONS: Among the 64 plasma samples of COVID-19 convalescents, whether vaccinated or not, Omicron (B.1.1.529) escaped the neutralizing antibodies, with a significantly decreased neutralization activity compared to WT. And two-dose of vaccine could significantly raise the average neutralization of Omicron in convalescent individuals. |
format | Online Article Text |
id | pubmed-9556728 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95567282022-10-14 Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variants Xie, Yudi Liu, Lei Wang, Jue Zheng, Yaqiong Luo, Chen Ni, Wenxu He, Zhihang Zhao, Xin Liu, Yan He, Yingyu Zheng, Shangen Li, Ling Liu, Zhong Front Immunol Immunology BACKGROUND: COVID-19 has caused a global pandemic and the death toll is increasing. With the coronavirus continuously mutating, Omicron has replaced Delta as the most widely reported variant in the world. Studies have shown that the plasma of some vaccinated people does not neutralize the Omicron variant. However, further studies are needed to determine whether plasma neutralizes Omicron after one- or two-dose vaccine in patients who have recovered from infection with the original strain. METHODS: The pseudovirus neutralization assays were performed on 64 plasma samples of convalescent COVID-19 patients, which were divided into pre-vaccination group, one-dose vaccinated group and two-dose vaccinated group. RESULTS: In the three groups, there were significant reductions of sera neutralizing activity from WT to Delta variant (B.1.617.2), and from WT to Omicron variant (B.1.1.529) (ps<0.001), but the difference between Delta and Omicron variants were not significant (p>0.05). The average neutralization of the Omicron variant showed a significant difference between pre-vaccination and two-dose vaccinated convalescent individuals (p<0.01). CONCLUSIONS: Among the 64 plasma samples of COVID-19 convalescents, whether vaccinated or not, Omicron (B.1.1.529) escaped the neutralizing antibodies, with a significantly decreased neutralization activity compared to WT. And two-dose of vaccine could significantly raise the average neutralization of Omicron in convalescent individuals. Frontiers Media S.A. 2022-09-29 /pmc/articles/PMC9556728/ /pubmed/36248883 http://dx.doi.org/10.3389/fimmu.2022.975533 Text en Copyright © 2022 Xie, Liu, Wang, Zheng, Luo, Ni, He, Zhao, Liu, He, Zheng, Li and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Xie, Yudi Liu, Lei Wang, Jue Zheng, Yaqiong Luo, Chen Ni, Wenxu He, Zhihang Zhao, Xin Liu, Yan He, Yingyu Zheng, Shangen Li, Ling Liu, Zhong Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variants |
title | Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variants |
title_full | Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variants |
title_fullStr | Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variants |
title_full_unstemmed | Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variants |
title_short | Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variants |
title_sort | neutralization effect of plasma from vaccinated covid-19 convalescents on sars-cov-2 omicron variants |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556728/ https://www.ncbi.nlm.nih.gov/pubmed/36248883 http://dx.doi.org/10.3389/fimmu.2022.975533 |
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