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Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variants

BACKGROUND: COVID-19 has caused a global pandemic and the death toll is increasing. With the coronavirus continuously mutating, Omicron has replaced Delta as the most widely reported variant in the world. Studies have shown that the plasma of some vaccinated people does not neutralize the Omicron va...

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Autores principales: Xie, Yudi, Liu, Lei, Wang, Jue, Zheng, Yaqiong, Luo, Chen, Ni, Wenxu, He, Zhihang, Zhao, Xin, Liu, Yan, He, Yingyu, Zheng, Shangen, Li, Ling, Liu, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556728/
https://www.ncbi.nlm.nih.gov/pubmed/36248883
http://dx.doi.org/10.3389/fimmu.2022.975533
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author Xie, Yudi
Liu, Lei
Wang, Jue
Zheng, Yaqiong
Luo, Chen
Ni, Wenxu
He, Zhihang
Zhao, Xin
Liu, Yan
He, Yingyu
Zheng, Shangen
Li, Ling
Liu, Zhong
author_facet Xie, Yudi
Liu, Lei
Wang, Jue
Zheng, Yaqiong
Luo, Chen
Ni, Wenxu
He, Zhihang
Zhao, Xin
Liu, Yan
He, Yingyu
Zheng, Shangen
Li, Ling
Liu, Zhong
author_sort Xie, Yudi
collection PubMed
description BACKGROUND: COVID-19 has caused a global pandemic and the death toll is increasing. With the coronavirus continuously mutating, Omicron has replaced Delta as the most widely reported variant in the world. Studies have shown that the plasma of some vaccinated people does not neutralize the Omicron variant. However, further studies are needed to determine whether plasma neutralizes Omicron after one- or two-dose vaccine in patients who have recovered from infection with the original strain. METHODS: The pseudovirus neutralization assays were performed on 64 plasma samples of convalescent COVID-19 patients, which were divided into pre-vaccination group, one-dose vaccinated group and two-dose vaccinated group. RESULTS: In the three groups, there were significant reductions of sera neutralizing activity from WT to Delta variant (B.1.617.2), and from WT to Omicron variant (B.1.1.529) (ps<0.001), but the difference between Delta and Omicron variants were not significant (p>0.05). The average neutralization of the Omicron variant showed a significant difference between pre-vaccination and two-dose vaccinated convalescent individuals (p<0.01). CONCLUSIONS: Among the 64 plasma samples of COVID-19 convalescents, whether vaccinated or not, Omicron (B.1.1.529) escaped the neutralizing antibodies, with a significantly decreased neutralization activity compared to WT. And two-dose of vaccine could significantly raise the average neutralization of Omicron in convalescent individuals.
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spelling pubmed-95567282022-10-14 Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variants Xie, Yudi Liu, Lei Wang, Jue Zheng, Yaqiong Luo, Chen Ni, Wenxu He, Zhihang Zhao, Xin Liu, Yan He, Yingyu Zheng, Shangen Li, Ling Liu, Zhong Front Immunol Immunology BACKGROUND: COVID-19 has caused a global pandemic and the death toll is increasing. With the coronavirus continuously mutating, Omicron has replaced Delta as the most widely reported variant in the world. Studies have shown that the plasma of some vaccinated people does not neutralize the Omicron variant. However, further studies are needed to determine whether plasma neutralizes Omicron after one- or two-dose vaccine in patients who have recovered from infection with the original strain. METHODS: The pseudovirus neutralization assays were performed on 64 plasma samples of convalescent COVID-19 patients, which were divided into pre-vaccination group, one-dose vaccinated group and two-dose vaccinated group. RESULTS: In the three groups, there were significant reductions of sera neutralizing activity from WT to Delta variant (B.1.617.2), and from WT to Omicron variant (B.1.1.529) (ps<0.001), but the difference between Delta and Omicron variants were not significant (p>0.05). The average neutralization of the Omicron variant showed a significant difference between pre-vaccination and two-dose vaccinated convalescent individuals (p<0.01). CONCLUSIONS: Among the 64 plasma samples of COVID-19 convalescents, whether vaccinated or not, Omicron (B.1.1.529) escaped the neutralizing antibodies, with a significantly decreased neutralization activity compared to WT. And two-dose of vaccine could significantly raise the average neutralization of Omicron in convalescent individuals. Frontiers Media S.A. 2022-09-29 /pmc/articles/PMC9556728/ /pubmed/36248883 http://dx.doi.org/10.3389/fimmu.2022.975533 Text en Copyright © 2022 Xie, Liu, Wang, Zheng, Luo, Ni, He, Zhao, Liu, He, Zheng, Li and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Xie, Yudi
Liu, Lei
Wang, Jue
Zheng, Yaqiong
Luo, Chen
Ni, Wenxu
He, Zhihang
Zhao, Xin
Liu, Yan
He, Yingyu
Zheng, Shangen
Li, Ling
Liu, Zhong
Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variants
title Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variants
title_full Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variants
title_fullStr Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variants
title_full_unstemmed Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variants
title_short Neutralization effect of plasma from vaccinated COVID-19 convalescents on SARS-CoV-2 Omicron variants
title_sort neutralization effect of plasma from vaccinated covid-19 convalescents on sars-cov-2 omicron variants
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556728/
https://www.ncbi.nlm.nih.gov/pubmed/36248883
http://dx.doi.org/10.3389/fimmu.2022.975533
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