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Infection of SARS-CoV-2 in domestic dogs associated with owner viral load
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive pet owners are reported to be a risk factor for infection of their pets; however, the influence of the viral load and associated risks has not been fully established. This study aimed to assess potential association of viral load...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556808/ https://www.ncbi.nlm.nih.gov/pubmed/36327620 http://dx.doi.org/10.1016/j.rvsc.2022.10.006 |
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author | de Souza Barbosa, Altina Bruna Kmetiuk, Louise Bach de Carvalho, Otávio Valério Brandão, Ana Pérola Drulla Doline, Fernando Rodrigo Lopes, Sibele Rejane Rangel Silveira Meira, Douglas Adamoski de Souza, Emanuel Maltempi da Silva Trindade, Edvaldo Baura, Valter Barbosa, David Soeiro Brandespim, Daniel Friguglietti Galhardo, Juliana Arena Pettan-Brewer, Christina de Sá Guimarães, Ana Marcia Dutra, Valéria de Morais, Hélio Autran Huergo, Luciano dos Santos, Andrea Pires Biondo, Alexander Welker |
author_facet | de Souza Barbosa, Altina Bruna Kmetiuk, Louise Bach de Carvalho, Otávio Valério Brandão, Ana Pérola Drulla Doline, Fernando Rodrigo Lopes, Sibele Rejane Rangel Silveira Meira, Douglas Adamoski de Souza, Emanuel Maltempi da Silva Trindade, Edvaldo Baura, Valter Barbosa, David Soeiro Brandespim, Daniel Friguglietti Galhardo, Juliana Arena Pettan-Brewer, Christina de Sá Guimarães, Ana Marcia Dutra, Valéria de Morais, Hélio Autran Huergo, Luciano dos Santos, Andrea Pires Biondo, Alexander Welker |
author_sort | de Souza Barbosa, Altina Bruna |
collection | PubMed |
description | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive pet owners are reported to be a risk factor for infection of their pets; however, the influence of the viral load and associated risks has not been fully established. This study aimed to assess potential association of viral load in owners with the presence of SARS-CoV-2 infection in their dogs. Of 20 SARS-CoV-2-positive pet owners from 13 families in Curitiba, Brazil, 5 of 22 (22.7%) dogs were positive for SARS-CoV-2. Viral presence was detected in oropharyngeal samples for 2 of 5 (40.0%) dogs at 8 and 9 days after the first positive sample. Detection of SARS-CoV-2 in these dogs was associated with higher viral loads in the owners and close owner contact. All 5 RT-qPCR-positive dogs had antibodies to at least one viral protein tested in the serological assay. Molecular detection of SARS-CoV-2 in dogs was statistically associated with clinical signs in owners such as cold, cough, or diarrhea (P = 0.039), number of positive persons in the household (P = 0.002), and higher viral load (P = 0.039). Such findings serve as a warning for risks of human to dog infection, mainly due to sharing beds and other close interactions without protection. In conclusion, people with coronavirus disease 2019 (COVID-19), particularly in households with multiple residents and high viral load, should take the same preventive measures when interacting with their dogs during self-isolation as they do with people. |
format | Online Article Text |
id | pubmed-9556808 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95568082022-10-16 Infection of SARS-CoV-2 in domestic dogs associated with owner viral load de Souza Barbosa, Altina Bruna Kmetiuk, Louise Bach de Carvalho, Otávio Valério Brandão, Ana Pérola Drulla Doline, Fernando Rodrigo Lopes, Sibele Rejane Rangel Silveira Meira, Douglas Adamoski de Souza, Emanuel Maltempi da Silva Trindade, Edvaldo Baura, Valter Barbosa, David Soeiro Brandespim, Daniel Friguglietti Galhardo, Juliana Arena Pettan-Brewer, Christina de Sá Guimarães, Ana Marcia Dutra, Valéria de Morais, Hélio Autran Huergo, Luciano dos Santos, Andrea Pires Biondo, Alexander Welker Res Vet Sci Article Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive pet owners are reported to be a risk factor for infection of their pets; however, the influence of the viral load and associated risks has not been fully established. This study aimed to assess potential association of viral load in owners with the presence of SARS-CoV-2 infection in their dogs. Of 20 SARS-CoV-2-positive pet owners from 13 families in Curitiba, Brazil, 5 of 22 (22.7%) dogs were positive for SARS-CoV-2. Viral presence was detected in oropharyngeal samples for 2 of 5 (40.0%) dogs at 8 and 9 days after the first positive sample. Detection of SARS-CoV-2 in these dogs was associated with higher viral loads in the owners and close owner contact. All 5 RT-qPCR-positive dogs had antibodies to at least one viral protein tested in the serological assay. Molecular detection of SARS-CoV-2 in dogs was statistically associated with clinical signs in owners such as cold, cough, or diarrhea (P = 0.039), number of positive persons in the household (P = 0.002), and higher viral load (P = 0.039). Such findings serve as a warning for risks of human to dog infection, mainly due to sharing beds and other close interactions without protection. In conclusion, people with coronavirus disease 2019 (COVID-19), particularly in households with multiple residents and high viral load, should take the same preventive measures when interacting with their dogs during self-isolation as they do with people. Elsevier Ltd. 2022-12-31 2022-10-13 /pmc/articles/PMC9556808/ /pubmed/36327620 http://dx.doi.org/10.1016/j.rvsc.2022.10.006 Text en © 2022 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article de Souza Barbosa, Altina Bruna Kmetiuk, Louise Bach de Carvalho, Otávio Valério Brandão, Ana Pérola Drulla Doline, Fernando Rodrigo Lopes, Sibele Rejane Rangel Silveira Meira, Douglas Adamoski de Souza, Emanuel Maltempi da Silva Trindade, Edvaldo Baura, Valter Barbosa, David Soeiro Brandespim, Daniel Friguglietti Galhardo, Juliana Arena Pettan-Brewer, Christina de Sá Guimarães, Ana Marcia Dutra, Valéria de Morais, Hélio Autran Huergo, Luciano dos Santos, Andrea Pires Biondo, Alexander Welker Infection of SARS-CoV-2 in domestic dogs associated with owner viral load |
title | Infection of SARS-CoV-2 in domestic dogs associated with owner viral load |
title_full | Infection of SARS-CoV-2 in domestic dogs associated with owner viral load |
title_fullStr | Infection of SARS-CoV-2 in domestic dogs associated with owner viral load |
title_full_unstemmed | Infection of SARS-CoV-2 in domestic dogs associated with owner viral load |
title_short | Infection of SARS-CoV-2 in domestic dogs associated with owner viral load |
title_sort | infection of sars-cov-2 in domestic dogs associated with owner viral load |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556808/ https://www.ncbi.nlm.nih.gov/pubmed/36327620 http://dx.doi.org/10.1016/j.rvsc.2022.10.006 |
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