P2X7 purinergic receptor plays a critical role in maintaining T-cell homeostasis and preventing lupus pathogenesis

The severe lymphoproliferative and lupus diseases developed by MRL/lpr mice depend on interactions between the Fas( lpr ) mutation and MRL genetic background. Thus, the Fas( lpr ) mutation causes limited disease in C57BL/6 mice. We previously found that accumulating B220(+) CD4(–)CD8(–) double negat...

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Detalles Bibliográficos
Autores principales: Mellouk, Amine, Hutteau-Hamel, Tom, Legrand, Julie, Safya, Hanaa, Benbijja, Mohcine, Mercier-Nomé, Françoise, Benihoud, Karim, Kanellopoulos, Jean M., Bobé, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556828/
https://www.ncbi.nlm.nih.gov/pubmed/36248812
http://dx.doi.org/10.3389/fimmu.2022.957008

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