Polyketides with IDH1 R132h and PTP1B inhibitory activities from the desert-plant-derived fungus Alternaria sp. HM 134

Five new polyketides named alternafurones A (1) and B (2), alternapyrones M-O (3–5), together with fourteen known ones (6–19), were isolated from the desert-plant-derived fungus Alternaria sp. HM 134. The structures of the new compounds were elucidated from spectroscopic data and ECD spectroscopic a...

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Autores principales: Li, Zhuang, Meng, Lu, Ma, Qingyun, Wang, Zhen, Zhao, Youxing, Luo, Duqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556845/
https://www.ncbi.nlm.nih.gov/pubmed/36246217
http://dx.doi.org/10.3389/fmicb.2022.975579
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author Li, Zhuang
Meng, Lu
Ma, Qingyun
Wang, Zhen
Zhao, Youxing
Luo, Duqiang
author_facet Li, Zhuang
Meng, Lu
Ma, Qingyun
Wang, Zhen
Zhao, Youxing
Luo, Duqiang
author_sort Li, Zhuang
collection PubMed
description Five new polyketides named alternafurones A (1) and B (2), alternapyrones M-O (3–5), together with fourteen known ones (6–19), were isolated from the desert-plant-derived fungus Alternaria sp. HM 134. The structures of the new compounds were elucidated from spectroscopic data and ECD spectroscopic analyses. Alternafurones A and B represent polyketides with an unprecedented 6/5/6 skeleton core. Compounds 1, 2 and 4 showed definite inhibitory activities against isocitrate dehydrogenase 1 gene (IDH1 R132h) with IC(50) values of 29.38, 19.41 and 14.14 μg/ml, respectively. Seven compounds (6, 7, 9–12, 14) showed potent protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with IC(50) values ranging from 0.97 μg/ml to 89.80 μg/ml.
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spelling pubmed-95568452022-10-14 Polyketides with IDH1 R132h and PTP1B inhibitory activities from the desert-plant-derived fungus Alternaria sp. HM 134 Li, Zhuang Meng, Lu Ma, Qingyun Wang, Zhen Zhao, Youxing Luo, Duqiang Front Microbiol Microbiology Five new polyketides named alternafurones A (1) and B (2), alternapyrones M-O (3–5), together with fourteen known ones (6–19), were isolated from the desert-plant-derived fungus Alternaria sp. HM 134. The structures of the new compounds were elucidated from spectroscopic data and ECD spectroscopic analyses. Alternafurones A and B represent polyketides with an unprecedented 6/5/6 skeleton core. Compounds 1, 2 and 4 showed definite inhibitory activities against isocitrate dehydrogenase 1 gene (IDH1 R132h) with IC(50) values of 29.38, 19.41 and 14.14 μg/ml, respectively. Seven compounds (6, 7, 9–12, 14) showed potent protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with IC(50) values ranging from 0.97 μg/ml to 89.80 μg/ml. Frontiers Media S.A. 2022-09-29 /pmc/articles/PMC9556845/ /pubmed/36246217 http://dx.doi.org/10.3389/fmicb.2022.975579 Text en Copyright © 2022 Li, Meng, Ma, Wang, Zhao and Luo. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Li, Zhuang
Meng, Lu
Ma, Qingyun
Wang, Zhen
Zhao, Youxing
Luo, Duqiang
Polyketides with IDH1 R132h and PTP1B inhibitory activities from the desert-plant-derived fungus Alternaria sp. HM 134
title Polyketides with IDH1 R132h and PTP1B inhibitory activities from the desert-plant-derived fungus Alternaria sp. HM 134
title_full Polyketides with IDH1 R132h and PTP1B inhibitory activities from the desert-plant-derived fungus Alternaria sp. HM 134
title_fullStr Polyketides with IDH1 R132h and PTP1B inhibitory activities from the desert-plant-derived fungus Alternaria sp. HM 134
title_full_unstemmed Polyketides with IDH1 R132h and PTP1B inhibitory activities from the desert-plant-derived fungus Alternaria sp. HM 134
title_short Polyketides with IDH1 R132h and PTP1B inhibitory activities from the desert-plant-derived fungus Alternaria sp. HM 134
title_sort polyketides with idh1 r132h and ptp1b inhibitory activities from the desert-plant-derived fungus alternaria sp. hm 134
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556845/
https://www.ncbi.nlm.nih.gov/pubmed/36246217
http://dx.doi.org/10.3389/fmicb.2022.975579
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