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Contribution of immune cells to bone metastasis pathogenesis

Bone metastasis is closely related to the survival rate of cancer patients and reduces their quality of life. The bone marrow microenvironment contains a complex immune cell component with a local microenvironment that is conducive to tumor formation and growth. In this unique immune environment, a...

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Detalles Bibliográficos
Autores principales: He, Ningning, Jiang, Jingting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556850/
https://www.ncbi.nlm.nih.gov/pubmed/36246916
http://dx.doi.org/10.3389/fendo.2022.1019864
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author He, Ningning
Jiang, Jingting
author_facet He, Ningning
Jiang, Jingting
author_sort He, Ningning
collection PubMed
description Bone metastasis is closely related to the survival rate of cancer patients and reduces their quality of life. The bone marrow microenvironment contains a complex immune cell component with a local microenvironment that is conducive to tumor formation and growth. In this unique immune environment, a variety of immune cells, including T cells, natural killer cells, macrophages, dendritic cells, and myeloid-derived suppressor cells, participate in the process of bone metastasis. In this review, we will introduce the interactions between immune cells and cancer cells in the bone microenvironment, obtain the details of their contributions to the implications of bone metastasis, and discuss immunotherapeutic strategies targeting immune cells in cancer patients with bone metastasis.
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spelling pubmed-95568502022-10-14 Contribution of immune cells to bone metastasis pathogenesis He, Ningning Jiang, Jingting Front Endocrinol (Lausanne) Endocrinology Bone metastasis is closely related to the survival rate of cancer patients and reduces their quality of life. The bone marrow microenvironment contains a complex immune cell component with a local microenvironment that is conducive to tumor formation and growth. In this unique immune environment, a variety of immune cells, including T cells, natural killer cells, macrophages, dendritic cells, and myeloid-derived suppressor cells, participate in the process of bone metastasis. In this review, we will introduce the interactions between immune cells and cancer cells in the bone microenvironment, obtain the details of their contributions to the implications of bone metastasis, and discuss immunotherapeutic strategies targeting immune cells in cancer patients with bone metastasis. Frontiers Media S.A. 2022-09-29 /pmc/articles/PMC9556850/ /pubmed/36246916 http://dx.doi.org/10.3389/fendo.2022.1019864 Text en Copyright © 2022 He and Jiang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
He, Ningning
Jiang, Jingting
Contribution of immune cells to bone metastasis pathogenesis
title Contribution of immune cells to bone metastasis pathogenesis
title_full Contribution of immune cells to bone metastasis pathogenesis
title_fullStr Contribution of immune cells to bone metastasis pathogenesis
title_full_unstemmed Contribution of immune cells to bone metastasis pathogenesis
title_short Contribution of immune cells to bone metastasis pathogenesis
title_sort contribution of immune cells to bone metastasis pathogenesis
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556850/
https://www.ncbi.nlm.nih.gov/pubmed/36246916
http://dx.doi.org/10.3389/fendo.2022.1019864
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AT jiangjingting contributionofimmunecellstobonemetastasispathogenesis