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Bilateral facial nerve palsy after COVID 19 vaccination

BACKGROUND: There has been lot of speculation around the possible side effects associated with COVID vaccination and incidence of facial palsy is one of them. Bilateral facial palsy is less likely to be idiopathic as compared to unilateral facial nerve palsy and warrants further investigations to fi...

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Autores principales: Kini, Ashwini, Abusamra, Khawla, Youseffi, Julie, Ryan, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556870/
http://dx.doi.org/10.1016/j.nerep.2022.100141
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author Kini, Ashwini
Abusamra, Khawla
Youseffi, Julie
Ryan, Stephen
author_facet Kini, Ashwini
Abusamra, Khawla
Youseffi, Julie
Ryan, Stephen
author_sort Kini, Ashwini
collection PubMed
description BACKGROUND: There has been lot of speculation around the possible side effects associated with COVID vaccination and incidence of facial palsy is one of them. Bilateral facial palsy is less likely to be idiopathic as compared to unilateral facial nerve palsy and warrants further investigations to find any secondary cause. COVID 19 infection and the vaccinations for the same are also included in the unique list of differentials. CASE REPORT: We report an interesting case of bilateral rapidly sequential facial nerve palsy following the administration of COVID vaccination that showed subsequent improvement. We provide literature review to report the current incidence of same, secondary to the vaccination as well the infection itself CASE PRESENTATION: Following the introduction of COVID 19 vaccine, there have been reports of various cranial nerve involvement including lower motor neuron type facial paresis. Bilateral facial palsy is less likely to be idiopathic as compared to unilateral palsy(23% vs 70%) and requires further work up to determine the etiology before determining to be idiopathic. Unilateral facial palsy(FP) has been reported in the Phase I and II trials for Pfizer and Moderna vaccine, with a total of 7 cases reported in these initial trials. To date, there is no direct evidence that these vaccines have increased the incidence of facial palsy as compared to adverse events reported with other vaccines or compared to COVID 19 infection itself. We report a unique case of bilateral lower motor neuron type facial palsy noted in a young male within hours of receiving the vaccine that later improved with treatment. Reports of simultaneous bilateral facial palsy after vaccine are rare with only few cases reported to date in literature. CONCLUSION: In conclusion from current available literature, we would like to postulate that though there is a risk of facial nerve palsy following the vaccination, it is comparable to the risks associated with any other vaccinations and not been higher than the non-vaccinated population. The overall risk is higher with the actual COVID 19 infection itself as compared to the vaccine.
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spelling pubmed-95568702022-10-16 Bilateral facial nerve palsy after COVID 19 vaccination Kini, Ashwini Abusamra, Khawla Youseffi, Julie Ryan, Stephen Neuroimmunology Reports Article BACKGROUND: There has been lot of speculation around the possible side effects associated with COVID vaccination and incidence of facial palsy is one of them. Bilateral facial palsy is less likely to be idiopathic as compared to unilateral facial nerve palsy and warrants further investigations to find any secondary cause. COVID 19 infection and the vaccinations for the same are also included in the unique list of differentials. CASE REPORT: We report an interesting case of bilateral rapidly sequential facial nerve palsy following the administration of COVID vaccination that showed subsequent improvement. We provide literature review to report the current incidence of same, secondary to the vaccination as well the infection itself CASE PRESENTATION: Following the introduction of COVID 19 vaccine, there have been reports of various cranial nerve involvement including lower motor neuron type facial paresis. Bilateral facial palsy is less likely to be idiopathic as compared to unilateral palsy(23% vs 70%) and requires further work up to determine the etiology before determining to be idiopathic. Unilateral facial palsy(FP) has been reported in the Phase I and II trials for Pfizer and Moderna vaccine, with a total of 7 cases reported in these initial trials. To date, there is no direct evidence that these vaccines have increased the incidence of facial palsy as compared to adverse events reported with other vaccines or compared to COVID 19 infection itself. We report a unique case of bilateral lower motor neuron type facial palsy noted in a young male within hours of receiving the vaccine that later improved with treatment. Reports of simultaneous bilateral facial palsy after vaccine are rare with only few cases reported to date in literature. CONCLUSION: In conclusion from current available literature, we would like to postulate that though there is a risk of facial nerve palsy following the vaccination, it is comparable to the risks associated with any other vaccinations and not been higher than the non-vaccinated population. The overall risk is higher with the actual COVID 19 infection itself as compared to the vaccine. The Authors. Published by Elsevier B.V. 2022 2022-10-13 /pmc/articles/PMC9556870/ http://dx.doi.org/10.1016/j.nerep.2022.100141 Text en © 2022 The Authors. Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Kini, Ashwini
Abusamra, Khawla
Youseffi, Julie
Ryan, Stephen
Bilateral facial nerve palsy after COVID 19 vaccination
title Bilateral facial nerve palsy after COVID 19 vaccination
title_full Bilateral facial nerve palsy after COVID 19 vaccination
title_fullStr Bilateral facial nerve palsy after COVID 19 vaccination
title_full_unstemmed Bilateral facial nerve palsy after COVID 19 vaccination
title_short Bilateral facial nerve palsy after COVID 19 vaccination
title_sort bilateral facial nerve palsy after covid 19 vaccination
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556870/
http://dx.doi.org/10.1016/j.nerep.2022.100141
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