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Crosstalk among N6-methyladenosine modification and RNAs in central nervous system injuries

Central nervous system (CNS) injuries, including traumatic brain injury (TBI), intracerebral hemorrhage (ICH) and ischemic stroke, are the most common cause of death and disability around the world. As the most common modification on ribonucleic acids (RNAs), N6-methyladenosine (m6A) modification ha...

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Autores principales: Tian, Mi, Mao, Lei, Zhang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556889/
https://www.ncbi.nlm.nih.gov/pubmed/36246528
http://dx.doi.org/10.3389/fncel.2022.1013450
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author Tian, Mi
Mao, Lei
Zhang, Li
author_facet Tian, Mi
Mao, Lei
Zhang, Li
author_sort Tian, Mi
collection PubMed
description Central nervous system (CNS) injuries, including traumatic brain injury (TBI), intracerebral hemorrhage (ICH) and ischemic stroke, are the most common cause of death and disability around the world. As the most common modification on ribonucleic acids (RNAs), N6-methyladenosine (m6A) modification has recently attracted great attentions due to its functions in determining the fate of RNAs through changes in splicing, translation, degradation and stability. A large number of studies have suggested that m6A modification played an important role in brain development and involved in many neurological disorders, particularly in CNS injuries. It has been proposed that m6A modification could improve neurological impairment, inhibit apoptosis, suppress inflammation, reduce pyroptosis and attenuate ferroptosis in CNS injuries via different molecules including phosphatase and tensin homolog (PTEN), NLR family pyrin domain containing 3 (NLRP3), B-cell lymphoma 2 (Bcl-2), glutathione peroxidase 4 (GPX4), and long non-coding RNA (lncRNA). Therefore, m6A modification showed great promise as potential targets in CNS injuries. In this article, we present a review highlighting the role of m6A modification in CNS injuries. Hence, on the basis of these properties and effects, m6A modification may be developed as therapeutic agents for CNS injury patients.
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spelling pubmed-95568892022-10-14 Crosstalk among N6-methyladenosine modification and RNAs in central nervous system injuries Tian, Mi Mao, Lei Zhang, Li Front Cell Neurosci Cellular Neuroscience Central nervous system (CNS) injuries, including traumatic brain injury (TBI), intracerebral hemorrhage (ICH) and ischemic stroke, are the most common cause of death and disability around the world. As the most common modification on ribonucleic acids (RNAs), N6-methyladenosine (m6A) modification has recently attracted great attentions due to its functions in determining the fate of RNAs through changes in splicing, translation, degradation and stability. A large number of studies have suggested that m6A modification played an important role in brain development and involved in many neurological disorders, particularly in CNS injuries. It has been proposed that m6A modification could improve neurological impairment, inhibit apoptosis, suppress inflammation, reduce pyroptosis and attenuate ferroptosis in CNS injuries via different molecules including phosphatase and tensin homolog (PTEN), NLR family pyrin domain containing 3 (NLRP3), B-cell lymphoma 2 (Bcl-2), glutathione peroxidase 4 (GPX4), and long non-coding RNA (lncRNA). Therefore, m6A modification showed great promise as potential targets in CNS injuries. In this article, we present a review highlighting the role of m6A modification in CNS injuries. Hence, on the basis of these properties and effects, m6A modification may be developed as therapeutic agents for CNS injury patients. Frontiers Media S.A. 2022-09-29 /pmc/articles/PMC9556889/ /pubmed/36246528 http://dx.doi.org/10.3389/fncel.2022.1013450 Text en Copyright © 2022 Tian, Mao and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular Neuroscience
Tian, Mi
Mao, Lei
Zhang, Li
Crosstalk among N6-methyladenosine modification and RNAs in central nervous system injuries
title Crosstalk among N6-methyladenosine modification and RNAs in central nervous system injuries
title_full Crosstalk among N6-methyladenosine modification and RNAs in central nervous system injuries
title_fullStr Crosstalk among N6-methyladenosine modification and RNAs in central nervous system injuries
title_full_unstemmed Crosstalk among N6-methyladenosine modification and RNAs in central nervous system injuries
title_short Crosstalk among N6-methyladenosine modification and RNAs in central nervous system injuries
title_sort crosstalk among n6-methyladenosine modification and rnas in central nervous system injuries
topic Cellular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556889/
https://www.ncbi.nlm.nih.gov/pubmed/36246528
http://dx.doi.org/10.3389/fncel.2022.1013450
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