Cargando…
Anti-aging efficacy of solid-state fermented ginseng with Aspergillus cristatus and its active metabolites
Aspergillus cristatus is a beneficial fungus of microbial fermented teas such as China’s Fuzhuan brick tea and Pu-erh tea, and is commonly called golden flower fungus (GFF) because its cleistothecium has a yellow millet or sand grain shape. Since natural materials fermented with GFF exhibit various...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556955/ https://www.ncbi.nlm.nih.gov/pubmed/36250021 http://dx.doi.org/10.3389/fmolb.2022.984307 |
_version_ | 1784807192011997184 |
---|---|
author | Park, Sang Cheol Ji, Yura Ryu, Jeoungjin Kyung, Seoyeon Kim, Minji Kang, Seunghyun Jang, Young Pyo |
author_facet | Park, Sang Cheol Ji, Yura Ryu, Jeoungjin Kyung, Seoyeon Kim, Minji Kang, Seunghyun Jang, Young Pyo |
author_sort | Park, Sang Cheol |
collection | PubMed |
description | Aspergillus cristatus is a beneficial fungus of microbial fermented teas such as China’s Fuzhuan brick tea and Pu-erh tea, and is commonly called golden flower fungus (GFF) because its cleistothecium has a yellow millet or sand grain shape. Since natural materials fermented with GFF exhibit various physiological activities, a new active cosmeceutical ingredient was developed by solid-state fermentation of ginseng, a famous active material for healthy skin, with GFF. The extract of solid-state fermented ginseng with GFF (GFFG) exhibited potent anti-aging efficacy on the skin such as the increase of hyaluronic acid synthesis, aquaporin expression, and mRNA level of filaggrin in HaCaT keratinocyte. GFFG also inhibited the expression of MMP-1 increased by TNF-α in human dermal fibroblast. Sophisticated chromatographic and spectroscopic studies have elucidated isodihydroauroglaucin and flavoglaucin as the metabolites which were not present in ginseng extract nor GFF extract alone. Bioassay of these metabolites revealed that these compounds were part of active principles of GFFG. These results suggest that GFFG would be a potential active ingredient in anti-aging cosmeceutical products. |
format | Online Article Text |
id | pubmed-9556955 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95569552022-10-14 Anti-aging efficacy of solid-state fermented ginseng with Aspergillus cristatus and its active metabolites Park, Sang Cheol Ji, Yura Ryu, Jeoungjin Kyung, Seoyeon Kim, Minji Kang, Seunghyun Jang, Young Pyo Front Mol Biosci Molecular Biosciences Aspergillus cristatus is a beneficial fungus of microbial fermented teas such as China’s Fuzhuan brick tea and Pu-erh tea, and is commonly called golden flower fungus (GFF) because its cleistothecium has a yellow millet or sand grain shape. Since natural materials fermented with GFF exhibit various physiological activities, a new active cosmeceutical ingredient was developed by solid-state fermentation of ginseng, a famous active material for healthy skin, with GFF. The extract of solid-state fermented ginseng with GFF (GFFG) exhibited potent anti-aging efficacy on the skin such as the increase of hyaluronic acid synthesis, aquaporin expression, and mRNA level of filaggrin in HaCaT keratinocyte. GFFG also inhibited the expression of MMP-1 increased by TNF-α in human dermal fibroblast. Sophisticated chromatographic and spectroscopic studies have elucidated isodihydroauroglaucin and flavoglaucin as the metabolites which were not present in ginseng extract nor GFF extract alone. Bioassay of these metabolites revealed that these compounds were part of active principles of GFFG. These results suggest that GFFG would be a potential active ingredient in anti-aging cosmeceutical products. Frontiers Media S.A. 2022-09-29 /pmc/articles/PMC9556955/ /pubmed/36250021 http://dx.doi.org/10.3389/fmolb.2022.984307 Text en Copyright © 2022 Park, Ji, Ryu, Kyung, Kim, Kang and Jang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Biosciences Park, Sang Cheol Ji, Yura Ryu, Jeoungjin Kyung, Seoyeon Kim, Minji Kang, Seunghyun Jang, Young Pyo Anti-aging efficacy of solid-state fermented ginseng with Aspergillus cristatus and its active metabolites |
title | Anti-aging efficacy of solid-state fermented ginseng with Aspergillus cristatus and its active metabolites |
title_full | Anti-aging efficacy of solid-state fermented ginseng with Aspergillus cristatus and its active metabolites |
title_fullStr | Anti-aging efficacy of solid-state fermented ginseng with Aspergillus cristatus and its active metabolites |
title_full_unstemmed | Anti-aging efficacy of solid-state fermented ginseng with Aspergillus cristatus and its active metabolites |
title_short | Anti-aging efficacy of solid-state fermented ginseng with Aspergillus cristatus and its active metabolites |
title_sort | anti-aging efficacy of solid-state fermented ginseng with aspergillus cristatus and its active metabolites |
topic | Molecular Biosciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556955/ https://www.ncbi.nlm.nih.gov/pubmed/36250021 http://dx.doi.org/10.3389/fmolb.2022.984307 |
work_keys_str_mv | AT parksangcheol antiagingefficacyofsolidstatefermentedginsengwithaspergilluscristatusanditsactivemetabolites AT jiyura antiagingefficacyofsolidstatefermentedginsengwithaspergilluscristatusanditsactivemetabolites AT ryujeoungjin antiagingefficacyofsolidstatefermentedginsengwithaspergilluscristatusanditsactivemetabolites AT kyungseoyeon antiagingefficacyofsolidstatefermentedginsengwithaspergilluscristatusanditsactivemetabolites AT kimminji antiagingefficacyofsolidstatefermentedginsengwithaspergilluscristatusanditsactivemetabolites AT kangseunghyun antiagingefficacyofsolidstatefermentedginsengwithaspergilluscristatusanditsactivemetabolites AT jangyoungpyo antiagingefficacyofsolidstatefermentedginsengwithaspergilluscristatusanditsactivemetabolites |