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Anti-aging efficacy of solid-state fermented ginseng with Aspergillus cristatus and its active metabolites

Aspergillus cristatus is a beneficial fungus of microbial fermented teas such as China’s Fuzhuan brick tea and Pu-erh tea, and is commonly called golden flower fungus (GFF) because its cleistothecium has a yellow millet or sand grain shape. Since natural materials fermented with GFF exhibit various...

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Autores principales: Park, Sang Cheol, Ji, Yura, Ryu, Jeoungjin, Kyung, Seoyeon, Kim, Minji, Kang, Seunghyun, Jang, Young Pyo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556955/
https://www.ncbi.nlm.nih.gov/pubmed/36250021
http://dx.doi.org/10.3389/fmolb.2022.984307
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author Park, Sang Cheol
Ji, Yura
Ryu, Jeoungjin
Kyung, Seoyeon
Kim, Minji
Kang, Seunghyun
Jang, Young Pyo
author_facet Park, Sang Cheol
Ji, Yura
Ryu, Jeoungjin
Kyung, Seoyeon
Kim, Minji
Kang, Seunghyun
Jang, Young Pyo
author_sort Park, Sang Cheol
collection PubMed
description Aspergillus cristatus is a beneficial fungus of microbial fermented teas such as China’s Fuzhuan brick tea and Pu-erh tea, and is commonly called golden flower fungus (GFF) because its cleistothecium has a yellow millet or sand grain shape. Since natural materials fermented with GFF exhibit various physiological activities, a new active cosmeceutical ingredient was developed by solid-state fermentation of ginseng, a famous active material for healthy skin, with GFF. The extract of solid-state fermented ginseng with GFF (GFFG) exhibited potent anti-aging efficacy on the skin such as the increase of hyaluronic acid synthesis, aquaporin expression, and mRNA level of filaggrin in HaCaT keratinocyte. GFFG also inhibited the expression of MMP-1 increased by TNF-α in human dermal fibroblast. Sophisticated chromatographic and spectroscopic studies have elucidated isodihydroauroglaucin and flavoglaucin as the metabolites which were not present in ginseng extract nor GFF extract alone. Bioassay of these metabolites revealed that these compounds were part of active principles of GFFG. These results suggest that GFFG would be a potential active ingredient in anti-aging cosmeceutical products.
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spelling pubmed-95569552022-10-14 Anti-aging efficacy of solid-state fermented ginseng with Aspergillus cristatus and its active metabolites Park, Sang Cheol Ji, Yura Ryu, Jeoungjin Kyung, Seoyeon Kim, Minji Kang, Seunghyun Jang, Young Pyo Front Mol Biosci Molecular Biosciences Aspergillus cristatus is a beneficial fungus of microbial fermented teas such as China’s Fuzhuan brick tea and Pu-erh tea, and is commonly called golden flower fungus (GFF) because its cleistothecium has a yellow millet or sand grain shape. Since natural materials fermented with GFF exhibit various physiological activities, a new active cosmeceutical ingredient was developed by solid-state fermentation of ginseng, a famous active material for healthy skin, with GFF. The extract of solid-state fermented ginseng with GFF (GFFG) exhibited potent anti-aging efficacy on the skin such as the increase of hyaluronic acid synthesis, aquaporin expression, and mRNA level of filaggrin in HaCaT keratinocyte. GFFG also inhibited the expression of MMP-1 increased by TNF-α in human dermal fibroblast. Sophisticated chromatographic and spectroscopic studies have elucidated isodihydroauroglaucin and flavoglaucin as the metabolites which were not present in ginseng extract nor GFF extract alone. Bioassay of these metabolites revealed that these compounds were part of active principles of GFFG. These results suggest that GFFG would be a potential active ingredient in anti-aging cosmeceutical products. Frontiers Media S.A. 2022-09-29 /pmc/articles/PMC9556955/ /pubmed/36250021 http://dx.doi.org/10.3389/fmolb.2022.984307 Text en Copyright © 2022 Park, Ji, Ryu, Kyung, Kim, Kang and Jang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Park, Sang Cheol
Ji, Yura
Ryu, Jeoungjin
Kyung, Seoyeon
Kim, Minji
Kang, Seunghyun
Jang, Young Pyo
Anti-aging efficacy of solid-state fermented ginseng with Aspergillus cristatus and its active metabolites
title Anti-aging efficacy of solid-state fermented ginseng with Aspergillus cristatus and its active metabolites
title_full Anti-aging efficacy of solid-state fermented ginseng with Aspergillus cristatus and its active metabolites
title_fullStr Anti-aging efficacy of solid-state fermented ginseng with Aspergillus cristatus and its active metabolites
title_full_unstemmed Anti-aging efficacy of solid-state fermented ginseng with Aspergillus cristatus and its active metabolites
title_short Anti-aging efficacy of solid-state fermented ginseng with Aspergillus cristatus and its active metabolites
title_sort anti-aging efficacy of solid-state fermented ginseng with aspergillus cristatus and its active metabolites
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556955/
https://www.ncbi.nlm.nih.gov/pubmed/36250021
http://dx.doi.org/10.3389/fmolb.2022.984307
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