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B cell deficiency promotes the initiation and progression of lung cancer

Currently commercialized CAR-T cell therapies targeting CD19 and BCMA show great efficacy to cure B cell malignancies. However, intravenous infusion of these CAR-T cells severely destroys both transformed and normal B cells in most tissues and organs, in particular lung, leading to a critical questi...

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Autores principales: Wu, Han, Chen, Chen, Gu, Lixing, Li, Jiapeng, Yue, Yunqiang, Lyu, Mengqing, Cui, Yeting, Zhang, Xiaoyu, Liu, Yu, Zhu, Haichuan, Liao, Xinghua, Zhang, Tongcun, Sun, Fan, Hu, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556970/
https://www.ncbi.nlm.nih.gov/pubmed/36249034
http://dx.doi.org/10.3389/fonc.2022.1006477
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author Wu, Han
Chen, Chen
Gu, Lixing
Li, Jiapeng
Yue, Yunqiang
Lyu, Mengqing
Cui, Yeting
Zhang, Xiaoyu
Liu, Yu
Zhu, Haichuan
Liao, Xinghua
Zhang, Tongcun
Sun, Fan
Hu, Weidong
author_facet Wu, Han
Chen, Chen
Gu, Lixing
Li, Jiapeng
Yue, Yunqiang
Lyu, Mengqing
Cui, Yeting
Zhang, Xiaoyu
Liu, Yu
Zhu, Haichuan
Liao, Xinghua
Zhang, Tongcun
Sun, Fan
Hu, Weidong
author_sort Wu, Han
collection PubMed
description Currently commercialized CAR-T cell therapies targeting CD19 and BCMA show great efficacy to cure B cell malignancies. However, intravenous infusion of these CAR-T cells severely destroys both transformed and normal B cells in most tissues and organs, in particular lung, leading to a critical question that what the impact of normal B cell depletion on pulmonary diseases and lung cancer is. Herein, we find that B cell frequency is remarkably reduced in both smoking carcinogen-treated lung tissues and lung tumors, which is associated with advanced cancer progression and worse patient survival. B cell depletion by anti-CD20 antibody significantly accelerates the initiation and progression of lung tumors, which is mediated by repressed tumor infiltration of T cells and macrophage elimination of tumor cells. These findings unveil the overall antitumor activity of B cells in lung cancer, providing novel insights into both mechanisms underlying lung cancer pathogenesis and clinical prevention post CAR-T cell therapy.
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spelling pubmed-95569702022-10-14 B cell deficiency promotes the initiation and progression of lung cancer Wu, Han Chen, Chen Gu, Lixing Li, Jiapeng Yue, Yunqiang Lyu, Mengqing Cui, Yeting Zhang, Xiaoyu Liu, Yu Zhu, Haichuan Liao, Xinghua Zhang, Tongcun Sun, Fan Hu, Weidong Front Oncol Oncology Currently commercialized CAR-T cell therapies targeting CD19 and BCMA show great efficacy to cure B cell malignancies. However, intravenous infusion of these CAR-T cells severely destroys both transformed and normal B cells in most tissues and organs, in particular lung, leading to a critical question that what the impact of normal B cell depletion on pulmonary diseases and lung cancer is. Herein, we find that B cell frequency is remarkably reduced in both smoking carcinogen-treated lung tissues and lung tumors, which is associated with advanced cancer progression and worse patient survival. B cell depletion by anti-CD20 antibody significantly accelerates the initiation and progression of lung tumors, which is mediated by repressed tumor infiltration of T cells and macrophage elimination of tumor cells. These findings unveil the overall antitumor activity of B cells in lung cancer, providing novel insights into both mechanisms underlying lung cancer pathogenesis and clinical prevention post CAR-T cell therapy. Frontiers Media S.A. 2022-09-29 /pmc/articles/PMC9556970/ /pubmed/36249034 http://dx.doi.org/10.3389/fonc.2022.1006477 Text en Copyright © 2022 Wu, Chen, Gu, Li, Yue, Lyu, Cui, Zhang, Liu, Zhu, Liao, Zhang, Sun and Hu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wu, Han
Chen, Chen
Gu, Lixing
Li, Jiapeng
Yue, Yunqiang
Lyu, Mengqing
Cui, Yeting
Zhang, Xiaoyu
Liu, Yu
Zhu, Haichuan
Liao, Xinghua
Zhang, Tongcun
Sun, Fan
Hu, Weidong
B cell deficiency promotes the initiation and progression of lung cancer
title B cell deficiency promotes the initiation and progression of lung cancer
title_full B cell deficiency promotes the initiation and progression of lung cancer
title_fullStr B cell deficiency promotes the initiation and progression of lung cancer
title_full_unstemmed B cell deficiency promotes the initiation and progression of lung cancer
title_short B cell deficiency promotes the initiation and progression of lung cancer
title_sort b cell deficiency promotes the initiation and progression of lung cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556970/
https://www.ncbi.nlm.nih.gov/pubmed/36249034
http://dx.doi.org/10.3389/fonc.2022.1006477
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