Cargando…

Rhodococcus strains as a good biotool for neutralizing pharmaceutical pollutants and obtaining therapeutically valuable products: Through the past into the future

Active pharmaceutical ingredients present a substantial risk when they reach the environment and drinking water sources. As a new type of dangerous pollutants with high chemical resistance and pronounced biological effects, they accumulate everywhere, often in significant concentrations (μg/L) in ec...

Descripción completa

Detalles Bibliográficos
Autores principales: Ivshina, Irina, Bazhutin, Grigory, Tyumina, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557007/
https://www.ncbi.nlm.nih.gov/pubmed/36246215
http://dx.doi.org/10.3389/fmicb.2022.967127
_version_ 1784807204910530560
author Ivshina, Irina
Bazhutin, Grigory
Tyumina, Elena
author_facet Ivshina, Irina
Bazhutin, Grigory
Tyumina, Elena
author_sort Ivshina, Irina
collection PubMed
description Active pharmaceutical ingredients present a substantial risk when they reach the environment and drinking water sources. As a new type of dangerous pollutants with high chemical resistance and pronounced biological effects, they accumulate everywhere, often in significant concentrations (μg/L) in ecological environments, food chains, organs of farm animals and humans, and cause an intense response from the aquatic and soil microbiota. Rhodococcus spp. (Actinomycetia class), which occupy a dominant position in polluted ecosystems, stand out among other microorganisms with the greatest variety of degradable pollutants and participate in natural attenuation, are considered as active agents with high transforming and degrading impacts on pharmaceutical compounds. Many representatives of rhodococci are promising as unique sources of specific transforming enzymes, quorum quenching tools, natural products and novel antimicrobials, biosurfactants and nanostructures. The review presents the latest knowledge and current trends regarding the use of Rhodococcus spp. in the processes of pharmaceutical pollutants’ biodegradation, as well as in the fields of biocatalysis and biotechnology for the production of targeted pharmaceutical products. The current literature sources presented in the review can be helpful in future research programs aimed at promoting Rhodococcus spp. as potential biodegraders and biotransformers to control pharmaceutical pollution in the environment.
format Online
Article
Text
id pubmed-9557007
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-95570072022-10-14 Rhodococcus strains as a good biotool for neutralizing pharmaceutical pollutants and obtaining therapeutically valuable products: Through the past into the future Ivshina, Irina Bazhutin, Grigory Tyumina, Elena Front Microbiol Microbiology Active pharmaceutical ingredients present a substantial risk when they reach the environment and drinking water sources. As a new type of dangerous pollutants with high chemical resistance and pronounced biological effects, they accumulate everywhere, often in significant concentrations (μg/L) in ecological environments, food chains, organs of farm animals and humans, and cause an intense response from the aquatic and soil microbiota. Rhodococcus spp. (Actinomycetia class), which occupy a dominant position in polluted ecosystems, stand out among other microorganisms with the greatest variety of degradable pollutants and participate in natural attenuation, are considered as active agents with high transforming and degrading impacts on pharmaceutical compounds. Many representatives of rhodococci are promising as unique sources of specific transforming enzymes, quorum quenching tools, natural products and novel antimicrobials, biosurfactants and nanostructures. The review presents the latest knowledge and current trends regarding the use of Rhodococcus spp. in the processes of pharmaceutical pollutants’ biodegradation, as well as in the fields of biocatalysis and biotechnology for the production of targeted pharmaceutical products. The current literature sources presented in the review can be helpful in future research programs aimed at promoting Rhodococcus spp. as potential biodegraders and biotransformers to control pharmaceutical pollution in the environment. Frontiers Media S.A. 2022-09-29 /pmc/articles/PMC9557007/ /pubmed/36246215 http://dx.doi.org/10.3389/fmicb.2022.967127 Text en Copyright © 2022 Ivshina, Bazhutin and Tyumina. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Ivshina, Irina
Bazhutin, Grigory
Tyumina, Elena
Rhodococcus strains as a good biotool for neutralizing pharmaceutical pollutants and obtaining therapeutically valuable products: Through the past into the future
title Rhodococcus strains as a good biotool for neutralizing pharmaceutical pollutants and obtaining therapeutically valuable products: Through the past into the future
title_full Rhodococcus strains as a good biotool for neutralizing pharmaceutical pollutants and obtaining therapeutically valuable products: Through the past into the future
title_fullStr Rhodococcus strains as a good biotool for neutralizing pharmaceutical pollutants and obtaining therapeutically valuable products: Through the past into the future
title_full_unstemmed Rhodococcus strains as a good biotool for neutralizing pharmaceutical pollutants and obtaining therapeutically valuable products: Through the past into the future
title_short Rhodococcus strains as a good biotool for neutralizing pharmaceutical pollutants and obtaining therapeutically valuable products: Through the past into the future
title_sort rhodococcus strains as a good biotool for neutralizing pharmaceutical pollutants and obtaining therapeutically valuable products: through the past into the future
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557007/
https://www.ncbi.nlm.nih.gov/pubmed/36246215
http://dx.doi.org/10.3389/fmicb.2022.967127
work_keys_str_mv AT ivshinairina rhodococcusstrainsasagoodbiotoolforneutralizingpharmaceuticalpollutantsandobtainingtherapeuticallyvaluableproductsthroughthepastintothefuture
AT bazhutingrigory rhodococcusstrainsasagoodbiotoolforneutralizingpharmaceuticalpollutantsandobtainingtherapeuticallyvaluableproductsthroughthepastintothefuture
AT tyuminaelena rhodococcusstrainsasagoodbiotoolforneutralizingpharmaceuticalpollutantsandobtainingtherapeuticallyvaluableproductsthroughthepastintothefuture