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Appendicular dedifferentiated chondrosarcoma: A management and survival study from the SEER database

INTRODUCTION: Dedifferentiated chondrosarcoma (DDC) is an aggressive osseous neoplasm with a dismal prognosis. Treatment commonly involves limb-salvage surgery or amputation. In patients with appendicular DDC, we sought to describe demographic, clinical and treatment characteristics (1), analyze ris...

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Autores principales: Gonzalez, Marcos R., Bryce-Alberti, Mayte, Portmann-Baracco, Arianna, Inchaustegui, Maria L., Castillo-Flores, Samy, Pretell-Mazzini, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557033/
https://www.ncbi.nlm.nih.gov/pubmed/36246299
http://dx.doi.org/10.1016/j.jbo.2022.100456
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author Gonzalez, Marcos R.
Bryce-Alberti, Mayte
Portmann-Baracco, Arianna
Inchaustegui, Maria L.
Castillo-Flores, Samy
Pretell-Mazzini, Juan
author_facet Gonzalez, Marcos R.
Bryce-Alberti, Mayte
Portmann-Baracco, Arianna
Inchaustegui, Maria L.
Castillo-Flores, Samy
Pretell-Mazzini, Juan
author_sort Gonzalez, Marcos R.
collection PubMed
description INTRODUCTION: Dedifferentiated chondrosarcoma (DDC) is an aggressive osseous neoplasm with a dismal prognosis. Treatment commonly involves limb-salvage surgery or amputation. In patients with appendicular DDC, we sought to describe demographic, clinical and treatment characteristics (1), analyze risk factors for metastasis (2) and overall death (3), and assess survival rates by treatment (4). MATERIALS AND METHODS: Two-hundred-and-five patients from the SEER Database were included in our analysis. Demographic, clinical and treatment variables were analyzed. Multivariate regression was performed to identify risk factors. Survival analysis was performed using the Kaplan-Meier method. RESULTS: Fifty-one (24.9 %) of the patients included presented metastasis at diagnosis. The most common locations were the lungs, other sites, and bone. Surgery to the primary site was more common in patients without metastasis (94.2 %) than those with (78.2 %); limb-salvage procedures were more common than amputations. Tumors >8 cm (T2) and those discontinuous (T3) were more likely to present metastasis at diagnosis (OR = 2.54, p = 0.043 and OR = 7.4, p = 0.008, respectively). Female gender was found to be a protective factor for overall death on crude analysis (OR = 0.33, p = 0.019). Metastases to sites other than the lungs (M1b) had the highest risk of overall death (OR = 49, p = 0.01). Combination of surgery and chemotherapy showed a trend towards higher overall survival in non-metastatic patients (p = 0.1069 and p = 0.1703). CONCLUSIONS: Appendicular DDC displays a high metastatic rate and low survival rates. The most common procedure is a limb-salvage surgery. Tumor size increases the risk of presenting metastases at diagnosis and female gender is a protective factor against death.
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spelling pubmed-95570332022-10-14 Appendicular dedifferentiated chondrosarcoma: A management and survival study from the SEER database Gonzalez, Marcos R. Bryce-Alberti, Mayte Portmann-Baracco, Arianna Inchaustegui, Maria L. Castillo-Flores, Samy Pretell-Mazzini, Juan J Bone Oncol Research Paper INTRODUCTION: Dedifferentiated chondrosarcoma (DDC) is an aggressive osseous neoplasm with a dismal prognosis. Treatment commonly involves limb-salvage surgery or amputation. In patients with appendicular DDC, we sought to describe demographic, clinical and treatment characteristics (1), analyze risk factors for metastasis (2) and overall death (3), and assess survival rates by treatment (4). MATERIALS AND METHODS: Two-hundred-and-five patients from the SEER Database were included in our analysis. Demographic, clinical and treatment variables were analyzed. Multivariate regression was performed to identify risk factors. Survival analysis was performed using the Kaplan-Meier method. RESULTS: Fifty-one (24.9 %) of the patients included presented metastasis at diagnosis. The most common locations were the lungs, other sites, and bone. Surgery to the primary site was more common in patients without metastasis (94.2 %) than those with (78.2 %); limb-salvage procedures were more common than amputations. Tumors >8 cm (T2) and those discontinuous (T3) were more likely to present metastasis at diagnosis (OR = 2.54, p = 0.043 and OR = 7.4, p = 0.008, respectively). Female gender was found to be a protective factor for overall death on crude analysis (OR = 0.33, p = 0.019). Metastases to sites other than the lungs (M1b) had the highest risk of overall death (OR = 49, p = 0.01). Combination of surgery and chemotherapy showed a trend towards higher overall survival in non-metastatic patients (p = 0.1069 and p = 0.1703). CONCLUSIONS: Appendicular DDC displays a high metastatic rate and low survival rates. The most common procedure is a limb-salvage surgery. Tumor size increases the risk of presenting metastases at diagnosis and female gender is a protective factor against death. Elsevier 2022-10-08 /pmc/articles/PMC9557033/ /pubmed/36246299 http://dx.doi.org/10.1016/j.jbo.2022.100456 Text en © 2022 The Authors. Published by Elsevier GmbH. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Paper
Gonzalez, Marcos R.
Bryce-Alberti, Mayte
Portmann-Baracco, Arianna
Inchaustegui, Maria L.
Castillo-Flores, Samy
Pretell-Mazzini, Juan
Appendicular dedifferentiated chondrosarcoma: A management and survival study from the SEER database
title Appendicular dedifferentiated chondrosarcoma: A management and survival study from the SEER database
title_full Appendicular dedifferentiated chondrosarcoma: A management and survival study from the SEER database
title_fullStr Appendicular dedifferentiated chondrosarcoma: A management and survival study from the SEER database
title_full_unstemmed Appendicular dedifferentiated chondrosarcoma: A management and survival study from the SEER database
title_short Appendicular dedifferentiated chondrosarcoma: A management and survival study from the SEER database
title_sort appendicular dedifferentiated chondrosarcoma: a management and survival study from the seer database
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557033/
https://www.ncbi.nlm.nih.gov/pubmed/36246299
http://dx.doi.org/10.1016/j.jbo.2022.100456
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