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The pro- and anti-tumoral properties of gap junctions in cancer and their role in therapeutic strategies
Gap junctions (GJs), essential structures for cell-cell communication, are made of two hemichannels (commonly called connexons), one on each adjacent cell. Found in almost all cells, GJs play a pivotal role in many physiological and cellular processes, and have even been linked to the progression of...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557036/ https://www.ncbi.nlm.nih.gov/pubmed/36228438 http://dx.doi.org/10.1016/j.redox.2022.102503 |
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author | Oliveira, Maria C. Verswyvel, Hanne Smits, Evelien Cordeiro, Rodrigo M. Bogaerts, Annemie Lin, Abraham |
author_facet | Oliveira, Maria C. Verswyvel, Hanne Smits, Evelien Cordeiro, Rodrigo M. Bogaerts, Annemie Lin, Abraham |
author_sort | Oliveira, Maria C. |
collection | PubMed |
description | Gap junctions (GJs), essential structures for cell-cell communication, are made of two hemichannels (commonly called connexons), one on each adjacent cell. Found in almost all cells, GJs play a pivotal role in many physiological and cellular processes, and have even been linked to the progression of diseases, such as cancer. Modulation of GJs is under investigation as a therapeutic strategy to kill tumor cells. Furthermore, GJs have also been studied for their key role in activating anti-cancer immunity and propagating radiation- and oxidative stress-induced cell death to neighboring cells, a process known as the bystander effect. While, gap junction (GJ)-based therapeutic strategies are being developed, one major challenge has been the paradoxical role of GJs in both tumor progression and suppression, based on GJ composition, cancer factors, and tumoral context. Therefore, understanding the mechanisms of action, regulation, and the dual characteristics of GJs in cancer is critical for developing effective therapeutics. In this review, we provide an overview of the current understanding of GJs structure, function, and paradoxical pro- and anti-tumoral role in cancer. We also discuss the treatment strategies to target these GJs properties for anti-cancer responses, via modulation of GJ function. |
format | Online Article Text |
id | pubmed-9557036 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-95570362022-10-14 The pro- and anti-tumoral properties of gap junctions in cancer and their role in therapeutic strategies Oliveira, Maria C. Verswyvel, Hanne Smits, Evelien Cordeiro, Rodrigo M. Bogaerts, Annemie Lin, Abraham Redox Biol Review Article Gap junctions (GJs), essential structures for cell-cell communication, are made of two hemichannels (commonly called connexons), one on each adjacent cell. Found in almost all cells, GJs play a pivotal role in many physiological and cellular processes, and have even been linked to the progression of diseases, such as cancer. Modulation of GJs is under investigation as a therapeutic strategy to kill tumor cells. Furthermore, GJs have also been studied for their key role in activating anti-cancer immunity and propagating radiation- and oxidative stress-induced cell death to neighboring cells, a process known as the bystander effect. While, gap junction (GJ)-based therapeutic strategies are being developed, one major challenge has been the paradoxical role of GJs in both tumor progression and suppression, based on GJ composition, cancer factors, and tumoral context. Therefore, understanding the mechanisms of action, regulation, and the dual characteristics of GJs in cancer is critical for developing effective therapeutics. In this review, we provide an overview of the current understanding of GJs structure, function, and paradoxical pro- and anti-tumoral role in cancer. We also discuss the treatment strategies to target these GJs properties for anti-cancer responses, via modulation of GJ function. Elsevier 2022-10-07 /pmc/articles/PMC9557036/ /pubmed/36228438 http://dx.doi.org/10.1016/j.redox.2022.102503 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Oliveira, Maria C. Verswyvel, Hanne Smits, Evelien Cordeiro, Rodrigo M. Bogaerts, Annemie Lin, Abraham The pro- and anti-tumoral properties of gap junctions in cancer and their role in therapeutic strategies |
title | The pro- and anti-tumoral properties of gap junctions in cancer and their role in therapeutic strategies |
title_full | The pro- and anti-tumoral properties of gap junctions in cancer and their role in therapeutic strategies |
title_fullStr | The pro- and anti-tumoral properties of gap junctions in cancer and their role in therapeutic strategies |
title_full_unstemmed | The pro- and anti-tumoral properties of gap junctions in cancer and their role in therapeutic strategies |
title_short | The pro- and anti-tumoral properties of gap junctions in cancer and their role in therapeutic strategies |
title_sort | pro- and anti-tumoral properties of gap junctions in cancer and their role in therapeutic strategies |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557036/ https://www.ncbi.nlm.nih.gov/pubmed/36228438 http://dx.doi.org/10.1016/j.redox.2022.102503 |
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