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Factors affecting RIG-I-Like receptors activation - New research direction for viral hemorrhagic fevers

Viral hemorrhagic fever (VHF) is a term referring to a group of life-threatening infections caused by several virus families (Arenaviridae, Bunyaviridae, Filoviridae and Flaviviridae). Depending on the virus, the infection can be mild and can be also characterized by an acute course with fever accom...

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Autores principales: Małkowska, Paulina, Niedźwiedzka-Rystwej, Paulina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557057/
https://www.ncbi.nlm.nih.gov/pubmed/36248895
http://dx.doi.org/10.3389/fimmu.2022.1010635
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author Małkowska, Paulina
Niedźwiedzka-Rystwej, Paulina
author_facet Małkowska, Paulina
Niedźwiedzka-Rystwej, Paulina
author_sort Małkowska, Paulina
collection PubMed
description Viral hemorrhagic fever (VHF) is a term referring to a group of life-threatening infections caused by several virus families (Arenaviridae, Bunyaviridae, Filoviridae and Flaviviridae). Depending on the virus, the infection can be mild and can be also characterized by an acute course with fever accompanied by hypervolemia and coagulopathy, resulting in bleeding and shock. It has been suggested that the course of the disease is strongly influenced by the activation of signaling pathways leading to RIG-I-like receptor-dependent interferon production. RIG-I-like receptors (RLRs) are one of two major receptor families that detect viral nucleic acid. RLR receptor activation is influenced by a number of factors that may have a key role in the differences that occur during the antiviral immune response in VHF. In the present study, we collected data on RLR receptors in viral hemorrhagic fevers and described factors that may influence the activation of the antiviral response. RLR receptors seem to be a good target for VHF research, which may contribute to better therapeutic and diagnostic strategies. However, due to the difficulty of conducting such studies in humans, we suggest using Lagovirus europaeus as an animal model for VHF.
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spelling pubmed-95570572022-10-14 Factors affecting RIG-I-Like receptors activation - New research direction for viral hemorrhagic fevers Małkowska, Paulina Niedźwiedzka-Rystwej, Paulina Front Immunol Immunology Viral hemorrhagic fever (VHF) is a term referring to a group of life-threatening infections caused by several virus families (Arenaviridae, Bunyaviridae, Filoviridae and Flaviviridae). Depending on the virus, the infection can be mild and can be also characterized by an acute course with fever accompanied by hypervolemia and coagulopathy, resulting in bleeding and shock. It has been suggested that the course of the disease is strongly influenced by the activation of signaling pathways leading to RIG-I-like receptor-dependent interferon production. RIG-I-like receptors (RLRs) are one of two major receptor families that detect viral nucleic acid. RLR receptor activation is influenced by a number of factors that may have a key role in the differences that occur during the antiviral immune response in VHF. In the present study, we collected data on RLR receptors in viral hemorrhagic fevers and described factors that may influence the activation of the antiviral response. RLR receptors seem to be a good target for VHF research, which may contribute to better therapeutic and diagnostic strategies. However, due to the difficulty of conducting such studies in humans, we suggest using Lagovirus europaeus as an animal model for VHF. Frontiers Media S.A. 2022-09-29 /pmc/articles/PMC9557057/ /pubmed/36248895 http://dx.doi.org/10.3389/fimmu.2022.1010635 Text en Copyright © 2022 Małkowska and Niedźwiedzka-Rystwej https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Małkowska, Paulina
Niedźwiedzka-Rystwej, Paulina
Factors affecting RIG-I-Like receptors activation - New research direction for viral hemorrhagic fevers
title Factors affecting RIG-I-Like receptors activation - New research direction for viral hemorrhagic fevers
title_full Factors affecting RIG-I-Like receptors activation - New research direction for viral hemorrhagic fevers
title_fullStr Factors affecting RIG-I-Like receptors activation - New research direction for viral hemorrhagic fevers
title_full_unstemmed Factors affecting RIG-I-Like receptors activation - New research direction for viral hemorrhagic fevers
title_short Factors affecting RIG-I-Like receptors activation - New research direction for viral hemorrhagic fevers
title_sort factors affecting rig-i-like receptors activation - new research direction for viral hemorrhagic fevers
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557057/
https://www.ncbi.nlm.nih.gov/pubmed/36248895
http://dx.doi.org/10.3389/fimmu.2022.1010635
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