Cargando…
Factors affecting RIG-I-Like receptors activation - New research direction for viral hemorrhagic fevers
Viral hemorrhagic fever (VHF) is a term referring to a group of life-threatening infections caused by several virus families (Arenaviridae, Bunyaviridae, Filoviridae and Flaviviridae). Depending on the virus, the infection can be mild and can be also characterized by an acute course with fever accom...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557057/ https://www.ncbi.nlm.nih.gov/pubmed/36248895 http://dx.doi.org/10.3389/fimmu.2022.1010635 |
_version_ | 1784807216918822912 |
---|---|
author | Małkowska, Paulina Niedźwiedzka-Rystwej, Paulina |
author_facet | Małkowska, Paulina Niedźwiedzka-Rystwej, Paulina |
author_sort | Małkowska, Paulina |
collection | PubMed |
description | Viral hemorrhagic fever (VHF) is a term referring to a group of life-threatening infections caused by several virus families (Arenaviridae, Bunyaviridae, Filoviridae and Flaviviridae). Depending on the virus, the infection can be mild and can be also characterized by an acute course with fever accompanied by hypervolemia and coagulopathy, resulting in bleeding and shock. It has been suggested that the course of the disease is strongly influenced by the activation of signaling pathways leading to RIG-I-like receptor-dependent interferon production. RIG-I-like receptors (RLRs) are one of two major receptor families that detect viral nucleic acid. RLR receptor activation is influenced by a number of factors that may have a key role in the differences that occur during the antiviral immune response in VHF. In the present study, we collected data on RLR receptors in viral hemorrhagic fevers and described factors that may influence the activation of the antiviral response. RLR receptors seem to be a good target for VHF research, which may contribute to better therapeutic and diagnostic strategies. However, due to the difficulty of conducting such studies in humans, we suggest using Lagovirus europaeus as an animal model for VHF. |
format | Online Article Text |
id | pubmed-9557057 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95570572022-10-14 Factors affecting RIG-I-Like receptors activation - New research direction for viral hemorrhagic fevers Małkowska, Paulina Niedźwiedzka-Rystwej, Paulina Front Immunol Immunology Viral hemorrhagic fever (VHF) is a term referring to a group of life-threatening infections caused by several virus families (Arenaviridae, Bunyaviridae, Filoviridae and Flaviviridae). Depending on the virus, the infection can be mild and can be also characterized by an acute course with fever accompanied by hypervolemia and coagulopathy, resulting in bleeding and shock. It has been suggested that the course of the disease is strongly influenced by the activation of signaling pathways leading to RIG-I-like receptor-dependent interferon production. RIG-I-like receptors (RLRs) are one of two major receptor families that detect viral nucleic acid. RLR receptor activation is influenced by a number of factors that may have a key role in the differences that occur during the antiviral immune response in VHF. In the present study, we collected data on RLR receptors in viral hemorrhagic fevers and described factors that may influence the activation of the antiviral response. RLR receptors seem to be a good target for VHF research, which may contribute to better therapeutic and diagnostic strategies. However, due to the difficulty of conducting such studies in humans, we suggest using Lagovirus europaeus as an animal model for VHF. Frontiers Media S.A. 2022-09-29 /pmc/articles/PMC9557057/ /pubmed/36248895 http://dx.doi.org/10.3389/fimmu.2022.1010635 Text en Copyright © 2022 Małkowska and Niedźwiedzka-Rystwej https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Małkowska, Paulina Niedźwiedzka-Rystwej, Paulina Factors affecting RIG-I-Like receptors activation - New research direction for viral hemorrhagic fevers |
title | Factors affecting RIG-I-Like receptors activation - New research direction for viral hemorrhagic fevers |
title_full | Factors affecting RIG-I-Like receptors activation - New research direction for viral hemorrhagic fevers |
title_fullStr | Factors affecting RIG-I-Like receptors activation - New research direction for viral hemorrhagic fevers |
title_full_unstemmed | Factors affecting RIG-I-Like receptors activation - New research direction for viral hemorrhagic fevers |
title_short | Factors affecting RIG-I-Like receptors activation - New research direction for viral hemorrhagic fevers |
title_sort | factors affecting rig-i-like receptors activation - new research direction for viral hemorrhagic fevers |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557057/ https://www.ncbi.nlm.nih.gov/pubmed/36248895 http://dx.doi.org/10.3389/fimmu.2022.1010635 |
work_keys_str_mv | AT małkowskapaulina factorsaffectingrigilikereceptorsactivationnewresearchdirectionforviralhemorrhagicfevers AT niedzwiedzkarystwejpaulina factorsaffectingrigilikereceptorsactivationnewresearchdirectionforviralhemorrhagicfevers |