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Molecular diagnostics in neurotrauma: Are there reliable biomarkers and effective methods for their detection?

To date, a large number of studies are being carried out in the field of neurotrauma, researchers not only establish the molecular mechanisms of the course of the disorders, but are also involved in the search for effective biomarkers for early prediction of the outcome and therapeutic intervention....

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Autores principales: Sabirov, Davran, Ogurcov, Sergei, Baichurina, Irina, Blatt, Nataliya, Rizvanov, Albert, Mukhamedshina, Yana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557129/
https://www.ncbi.nlm.nih.gov/pubmed/36250009
http://dx.doi.org/10.3389/fmolb.2022.1017916
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author Sabirov, Davran
Ogurcov, Sergei
Baichurina, Irina
Blatt, Nataliya
Rizvanov, Albert
Mukhamedshina, Yana
author_facet Sabirov, Davran
Ogurcov, Sergei
Baichurina, Irina
Blatt, Nataliya
Rizvanov, Albert
Mukhamedshina, Yana
author_sort Sabirov, Davran
collection PubMed
description To date, a large number of studies are being carried out in the field of neurotrauma, researchers not only establish the molecular mechanisms of the course of the disorders, but are also involved in the search for effective biomarkers for early prediction of the outcome and therapeutic intervention. Particular attention is paid to traumatic brain injury and spinal cord injury, due to the complex cascade of reactions in primary and secondary injury that affect pathophysiological processes and regenerative potential of the central nervous system. Despite a wide range of methods available methods to study biomarkers that correlate with the severity and degree of recovery in traumatic brain injury and spinal cord injury, development of reliable test systems for clinical use continues. In this review, we evaluate the results of recent studies looking for various molecules acting as biomarkers in the abovementioned neurotrauma. We also summarize the current knowledge of new methods for studying biological molecules, analyzing their sensitivity and limitations, as well as reproducibility of results. In this review, we also highlight the importance of developing reliable and reproducible protocols to identify diagnostic and prognostic biomolecules.
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spelling pubmed-95571292022-10-14 Molecular diagnostics in neurotrauma: Are there reliable biomarkers and effective methods for their detection? Sabirov, Davran Ogurcov, Sergei Baichurina, Irina Blatt, Nataliya Rizvanov, Albert Mukhamedshina, Yana Front Mol Biosci Molecular Biosciences To date, a large number of studies are being carried out in the field of neurotrauma, researchers not only establish the molecular mechanisms of the course of the disorders, but are also involved in the search for effective biomarkers for early prediction of the outcome and therapeutic intervention. Particular attention is paid to traumatic brain injury and spinal cord injury, due to the complex cascade of reactions in primary and secondary injury that affect pathophysiological processes and regenerative potential of the central nervous system. Despite a wide range of methods available methods to study biomarkers that correlate with the severity and degree of recovery in traumatic brain injury and spinal cord injury, development of reliable test systems for clinical use continues. In this review, we evaluate the results of recent studies looking for various molecules acting as biomarkers in the abovementioned neurotrauma. We also summarize the current knowledge of new methods for studying biological molecules, analyzing their sensitivity and limitations, as well as reproducibility of results. In this review, we also highlight the importance of developing reliable and reproducible protocols to identify diagnostic and prognostic biomolecules. Frontiers Media S.A. 2022-09-29 /pmc/articles/PMC9557129/ /pubmed/36250009 http://dx.doi.org/10.3389/fmolb.2022.1017916 Text en Copyright © 2022 Sabirov, Ogurcov, Baichurina, Blatt, Rizvanov and Mukhamedshina. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Sabirov, Davran
Ogurcov, Sergei
Baichurina, Irina
Blatt, Nataliya
Rizvanov, Albert
Mukhamedshina, Yana
Molecular diagnostics in neurotrauma: Are there reliable biomarkers and effective methods for their detection?
title Molecular diagnostics in neurotrauma: Are there reliable biomarkers and effective methods for their detection?
title_full Molecular diagnostics in neurotrauma: Are there reliable biomarkers and effective methods for their detection?
title_fullStr Molecular diagnostics in neurotrauma: Are there reliable biomarkers and effective methods for their detection?
title_full_unstemmed Molecular diagnostics in neurotrauma: Are there reliable biomarkers and effective methods for their detection?
title_short Molecular diagnostics in neurotrauma: Are there reliable biomarkers and effective methods for their detection?
title_sort molecular diagnostics in neurotrauma: are there reliable biomarkers and effective methods for their detection?
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9557129/
https://www.ncbi.nlm.nih.gov/pubmed/36250009
http://dx.doi.org/10.3389/fmolb.2022.1017916
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